MilliporeSigma™ Calbiochem™ CXCR4 Antagonist IV, TF14016
A 14-aa internally disulfide-bonded peptide that potently competes against SDF-1α/CXCL12 for CXCR4 binding (IC50
Supplier: MilliporeSigma™ 5.00507.0001
DescriptionA 14-aa internally disulfide-bonded peptide that potently competes against SDF-1α/CXCL12 for CXCR4 binding (IC50 = 0.91nM; [SDF-1] = 100nM) and protects MT-4 cells against X4-HIV strain HIV-1IIIB infection (EC50 = 4nM in 5 d; MOI = 0.01) with no significant cytotoxicity (CC50 = 56μM; 5 d). Inhibits SDF-1-induced Ca2+ mobilization (IC50 = 4.5nM; [SDF-1] = 30nM; CXCR4-expressing CHO cells) in vitro and effectively prevents CXCR4-dependent 5BC-5 metastasis in NK-depleted SCID mice in vivo (10mg/kg i.p.) in vivo .
Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
|Supplied as a trifluoroacetate salt.|
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