MilliporeSigma™ Calbiochem™ CXCR4 Antagonist IV, TF14016

A 14-aa internally disulfide-bonded peptide that potently competes against SDF-1α/CXCL12 for CXCR4 binding (IC₅₀

Supplier:  MilliporeSigma™ 5.00507.0001

Catalog No. 50-050-70001

Description

A 14-aa internally disulfide-bonded peptide that potently competes against SDF-1α/CXCL12 for CXCR4 binding (IC₅₀ = 0.91nM; [SDF-1] = 100nM) and protects MT-4 cells against X4-HIV strain HIV-1_IIIB infection (EC₅₀ = 4nM in 5 d; MOI = 0.01) with no significant cytotoxicity (CC₅₀ = 56μM; 5 d). Inhibits SDF-1-induced Ca²⁺ mobilization (IC₅₀ = 4.5nM; [SDF-1] = 30nM; CXCR4-expressing CHO cells) in vitro and effectively prevents CXCR4-dependent 5BC-5 metastasis in NK-depleted SCID mice in vivo (10mg/kg i.p.) in vivo .

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.

Specifications

• Form: Solid
• Color: White
• Molecular Formula: C₁₀₁H₁₄₅FN₃₄O₁₈S₂·xH₂O

• Quantity: 2 mg
• Formulation: Supplied as a trifluoroacetate salt.