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MilliporeSigma™ Calbiochem™ EphA Antagonist

Catalog No. 5007130001 Shop All MilliporeSigma Products
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50-071-30001 10 mg
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Catalog No. 50-071-30001 Supplier MilliporeSigma™ Supplier No. 5007130001
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Description

A pyrrolyl benzoic acid that effectively competes against ephrin-B3 for EphA4 binding as well as against ephrin-A1/-A2/-A3/-A5 for EphA2 and EphA4 binding by targeting EphA2/A4 high affinity ephrin-binding pocket in a reversible manner, exhibiting much reduced or no potency against ephrin-A4 for EphA2/EphA4 binding, ephrin-A5 for EphA3/A5/A6/A7 binding, ephrin-B2 for B1/B2/B3/B4/B6 binding, or ephrin-B2 for EphA4 binding

A pyrrolyl benzoic acid that effectively competes against ephrin-B3 for EphA4 binding as well as against ephrin-A1/-A2/-A3/-A5 for EphA2 and EphA4 binding by targeting EphA2/A4 high affinity ephrin-binding pocket in a reversible manner, exhibiting much reduced or no potency against ephrin-A4 for EphA2/EphA4 binding, ephrin-A5 for EphA3/A5/A6/A7 binding, ephrin-B2 for B1/B2/B3/B4/B6 binding, or ephrin-B2 for EphA4 binding. Shown to inhibit ephrin-A1-induced EphA2 phosphorylation (by 92% at 200μM) and ephrin-A5-induced EphA4 phosphorylation (by 79% at 400μM) in cultures in vitro and prevent ephrin-A5-induced growth cone collapse of neurons in 6-d chicken embryo retina (by 100% at 400μM) ex vivo , as well as rescue human mutant SOD-1 A4V transgene-induced axonopathy in zebrafish embryos (500μM from 6 to 30 hpf) in vivo .
TRUSTED_SUSTAINABILITY

Specifications

Color Orange
Description 95% by HPLC
Target Proteins EphA
Molecular Formula C13H13NO3
Formula Weight 231.25g/mol
Solubility DMSO
Content And Storage Protect from light
Form Powder
Quantity 10 mg
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