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MilliporeSigma™ Calbiochem™ JHDM Inhibitor VIII, SD70
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Quantity:
25 mg
Description
A cell-permeable, bioavailable, non-toxic 8-hydroxyquinolinyl based compound that binds to and colocalizes with androgen receptor (AR) at both ligand-dependent and independent transcriptional regulatory elements. Acts as an inhibitor of dihydotestosterone-regulated gene expression. Shown to inhibit prostate cancer cell transcription by blocking the activity of histone lysine demethylase KDM4C (IC50 = 30μM). Increases total H3K9me2 levels in 293 T cells in enhancer and promoter regions and causes a slight diminution in the levels of methylated H3K36. Does not affect the activity of DNA/RNA polymerase or topoisomerase I and II activities in any significant manner. Blocks the proliferation of hormone-independent CWR22Rv1 cells in culture (∽ 5μM) and also inhibits their growth in a prostate cancer xenograft murine model (10mg/kg, i.p.daily).
Please note that the molecular weight for this compound is batch-specific due to variable water content.
Please note that the molecular weight for this compound is batch-specific due to variable water content.

Specifications
Specifications
Color | Off-white |
Description | 97% by HPLC |
Target Proteins | JMJD2C/KDM4C |
Molecular Formula | C18H18N2O3 |
Solubility | DMSO |
Content And Storage | Protect from light |
Form | Powder |
Quantity | 25 mg |
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