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MilliporeSigma™ Calbiochem™ LRH-1 Antagonist

Catalog No. 5056010001 Shop All MilliporeSigma Products
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25 mg
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Catalog No. Quantity
50-560-10001 25 mg
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Catalog No. 50-560-10001 Supplier MilliporeSigma™ Supplier No. 5056010001
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Description

A cell-permeable pyrazolylbiphenylethanone compound that targets LRH-1/NR5A2 ligand binding domain (LBD) via direct affinity interaction (Kd = 1

A cell-permeable pyrazolylbiphenylethanone compound that targets LRH-1/NR5A2 ligand binding domain (LBD) via direct affinity interaction (Kd = 1.5μM), preventing LRH-1 from assuming an active conformation. Shown to antagonize LRH-1-, but not SF-1-, dependent G0S2 transcription (IC50 = 5μM using HEK293 transfectants), while exhibiting no inhibitory effect against AR, ERα, or TRβ transcription activity at concentrations up to 10μM. Reported to exhibits non-cytotoxic antiproliferation activity in LRH-1-expressing cancer cultures (15 to 20μM), but not pancreatic cancer L3.3 line that does not express LRH-1 (20% inhibition at 40μM).
TRUSTED_SUSTAINABILITY

Specifications

Color Pale Yellow
Description 98% by HPLC
Target Proteins LRH-1
Molecular Formula C23H25N3O2
Solubility DMSO
Content And Storage Protect from light
Form Solid
Quantity 25 mg
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