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MilliporeSigma™ Calbiochem™ MELK Inhibitor, OTSSP167

Catalog No. 5326040001 Shop All MilliporeSigma Products
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53-260-40001 5 mg
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Catalog No. 53-260-40001 Supplier MilliporeSigma™ Supplier No. 5.32604.0001

Description

A cell permeable, orally bioavailable 1, 5-naphthyridine based compound that acts as a highly potent and specific inhibitor of maternal embryonic leucine zipper kinase (MELK; IC50 = 410)

A cell permeable, orally bioavailable 1, 5-naphthyridine based compound that acts as a highly potent and specific inhibitor of maternal embryonic leucine zipper kinase (MELK; IC50 = 410 pM). Inhibits mammospheres formation of MDA-MB-231 and MCF-7 cells by blocking MELK-dependent phosphorylation of proteasome subunit a1 (PSMA1). Also diminishes the phosphorylation of Ser269 on drebin-like (DBNL) in BT549 cells and reduces their invasiveness. Suppresses the growth of xenografted MDA-MD-231 cells in a murine model (20mg/kg, once every 2 days for 14 days, i.v). Induces the formation of autophagosome-like vesicles in cytoplasm of BT549 breast cancer cells. Also shown to suppress the growth of lung, pancreatic, and prostate cancer cells expressing high levels of MELK.

Please note that the molecular weight for this compound is batch-specific due to variable water content.
TRUSTED_SUSTAINABILITY

Specifications

Color Beige
Description 98% by HPLC
Target Proteins MELK
Molecular Formula C25H30Cl4N4O2
Solubility DMSO or H2O
Content And Storage Protect from light
Form Powder
Quantity 5 mg
Product Title
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