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MilliporeSigma™ Calbiochem™ MMP/TACE Substrate, FS-6

Catalog No. 4442821MG Shop All MilliporeSigma Products
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44-428-21MG 1 mg
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Catalog No. 44-428-21MG Supplier MilliporeSigma™ Supplier No. 4442821MG

Description

The widely used MMP substrate FS-1 is modified by an N-terminal lysine elongation to produce a broad-spectrum MMP and TACE substrate that displays improved water solubility and substrate sensitivities.

The widely used MMP substrate FS-1 (Cat. No.03-32-5032) is modified by an N-terminal lysine elongation to produce a broad-spectrum MMP and TACE substrate that displays improved water solubility and substrate sensitivities. Exhibits 2- to 9-fold higher specificity constant (kcat/Km) towards MMP-1, -8, -13, -14 when compared with FS-1 and ∽2-fold higher kcat/Km towards TACE when compared with TACE Substrate II and III (Cat. Nos. 616402 and 616403, respectively). It has been used successfully in detecting T98G glioma cell surface-associated MMP activity and is shown to be resistant to proteolysis by human leukocyte elastase, trypsin, and ADAM-10.
TRUSTED_SUSTAINABILITY

Specifications

Formulation Supplied as a trifluoroacetate salt.
Description 97% by HPLC
Target Proteins Broad-spectrum MMP and TACE substrate
Molecular Formula C55H80N16O16
Formula Weight 1221.3g/mol
Solubility H2O or 5% Acetic Acid
Content And Storage Hygroscopic, Protect from light
Form Lyophilized
Quantity 1 mg
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