MilliporeSigma™ Calbiochem™ MMP/TACE Substrate, FS-6

Description

The widely used MMP substrate FS-1 is modified by an N-terminal lysine elongation to produce a broad-spectrum MMP and TACE substrate that displays improved water solubility and substrate sensitivities.

The widely used MMP substrate FS-1 (Cat. No.03-32-5032) is modified by an N-terminal lysine elongation to produce a broad-spectrum MMP and TACE substrate that displays improved water solubility and substrate sensitivities. Exhibits 2- to 9-fold higher specificity constant (k_cat/K_m) towards MMP-1, -8, -13, -14 when compared with FS-1 and ∽2-fold higher k_cat/K_m towards TACE when compared with TACE Substrate II and III (Cat. Nos. 616402 and 616403, respectively). It has been used successfully in detecting T98G glioma cell surface-associated MMP activity and is shown to be resistant to proteolysis by human leukocyte elastase, trypsin, and ADAM-10.

Specifications

• Formulation: Supplied as a trifluoroacetate salt.
• Description: 97% by HPLC
• Target Proteins: Broad-spectrum MMP and TACE substrate
• Molecular Formula: C₅₅H₈₀N₁₆O₁₆
• Formula Weight: 1221.3g/mol
• Solubility: H₂O or 5% Acetic Acid
• Content And Storage: Hygroscopic, Protect from light
• Form: Lyophilized
• Quantity: 1 mg