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MilliporeSigma™ Calbiochem™ Prostaglandin EP2 Receptor Antagonist, TG6-10-1

Catalog No. 5057650001 Shop All MilliporeSigma Products
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50-576-50001 10 mg
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Catalog No. 50-576-50001 Supplier MilliporeSigma™ Supplier No. 5057650001
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Description

A cell-permeable, 3-acryl-acrylamide derivative that acts as a highly potent, selective, and competitive antagonist of prostaglandin E2 receptor (EP2, Kb =

A cell-permeable, 3-acryl-acrylamide derivative that acts as a highly potent, selective, and competitive antagonist of prostaglandin E2 receptor (EP2, Kb = 17.8nM). Exhibits about 300-fold selectivity for the EP2 receptor over human EP3, EP4, and IP receptors, about 100- fold selectivity over human EP1, 25-fold selectivity against human FP and TP, and 10-fold selectivity against human DP1 receptors. Does not affect the activity of about 40 enzymes, ion channels, receptors, and neurotransmitters even at higher concentrations (˜10μM). Shown to significantly reduce the induction of several inflammatory cytokines and chemokines and reduces the opening of blood-brain barrier during neuronal inflammation. Displays good pharmacokinetic properties with a half-life of 1.6 h and brain to plasma ratio of 1.6 in a murine model (5mg/kg i.p.).
TRUSTED_SUSTAINABILITY

Specifications

Color White
Description 98% by HPLC
Target Proteins EP2
Molecular Formula C23H23F3N2O4
Solubility DMSO
Content And Storage Protect from light
Form Powder
Quantity 10 mg
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