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MilliporeSigma™ Calbiochem™ TrkB Antagonist, ANA-12

Catalog No. 5063040001 Shop All MilliporeSigma Products
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25 mg
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50-630-40001 25 mg
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Catalog No. 50-630-40001 Supplier MilliporeSigma™ Supplier No. 5063040001
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Description

A cell-permeable thiophene carboxymide derived compound that acts as a direct and selective antagonist of TrkB receptor

A cell-permeable thiophene carboxymide derived compound that acts as a direct and selective antagonist of TrkB receptor. Binds to the high affinity site on the extracellular domain of TrkB in a dose-dependent manner (Kd = 10nM) exhibiting much reduced binding to the low affinity site (Kd =12μM) indicating that it does not compete with BDNF for the same binding site. Does not affect TrkA or TrkC receptors. Shown to permeate the blood-brain barrier, however, its antagonistic effects are not uniform throughout the brain. Does not affect the survivability of neurons. Reduces anxiety and depression related behavior in mice.
TRUSTED_SUSTAINABILITY

Specifications

Color White
Description 98% by HPLC
Target Proteins TrkB
Molecular Formula C22H21N3O3S
Solubility DMSO
Content And Storage Protect from light
Form Solid
Quantity 25 mg
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