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Apexbio Technology LLC BS-181 1092443-52-1 25mg
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Supplier:  Apexbio Technology LLC A326625

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BS-181 (CAS 1092443-52-1) is a small molecule inhibitor developed to selectively target cyclin-dependent kinase 7 (CDK7) a regulator of cell cycle progression In in vitro kinase assays BS-181 demonstrates a 35-fold selectivity for CDK7 over CDK2 with an IC50 of 880 nM for CDK7 BS-181 inhibits phosphorylation of CDK7 substrates in MCF-7 cancer cells resulting in cell cycle arrest and induction of apoptosis thereby suppressing cancer cell proliferation In vivo studies show that BS-181 is stable following intraperitoneal administration and reduces tumor growth in MCF-7 xenograft models BS-181 serves as a useful tool for probing CDK7 function and potential anti-tumor effects in preclinical research

Catalog No. 50-000-92880


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