Invitrogen™ Calmodulin 2 Polyclonal Antibody

Catalog No.	Quantity
PIPA5121166	100 μL

Catalog No. PIPA5121166 Supplier Invitrogen™ Supplier No. PA5121166

Description

Rabbit Polyclonal Antibody

Positive test controls include: NIH/3T3, MCF7, BT-474, NCI-H460, Mouse brain. The target is usually found in the following locations: Cytoplasm, cytoskeleton, spindle, spindle pole. Immunogen sequence: MADQLTEEQI AEFKEAFSLF DKDGDGTITT KELGTVMRSL GQNPTEAELQ DMINEVDADG NGTIDFPEFL TMMARKMKDT DSEEEIREAF RVFDKDGNGY ISAAELRHVM TNLGEKLTDE EVDEMIREAD IDGDGQVNYE EFVQMMTAK.

Calmodulin 2 (CALM2) is one of the three human genes encoding calmodulin, a highly conserved calcium-binding messenger protein critical for mediating various cellular processes. Calmodulin proteins are composed of two pairs of EF-hand motifs located at both the N- and C-termini, connected by a flexible central linker. Each EF-hand motif binds calcium ions, with the C-terminus possessing two high-affinity Ca2+ binding sites, while the N-terminus contains two low-affinity sites. Upon binding calcium, calmodulin undergoes a conformational change that enables it to interact with and regulate numerous target proteins, including kinases, phosphatases, ion channels, and other enzymes. Specifically, calcium/calmodulin (CaM) signaling pathways are involved in critical cellular functions such as muscle contraction, neurotransmitter release, and cellular growth. The interaction of CALM2 with different targets is essential for translating transient changes in intracellular calcium levels into specific cellular responses, making it a pivotal player in calcium signaling.

Specifications

• Antigen: Calmodulin 2
• Applications: ELISA, Western Blot
• Classification: Polyclonal
• Concentration: 1.08 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: CALM2
• Gene Accession No.: P0DP24, P0DP27
• Gene Alias: 1500001E21Rik; AL024017; Calm; Calm1; CALM2; Calm3; CALML2; calmodulin; calmodulin 2; calmodulin 2 (phosphorylase kinase, delta); Calmodulin-1; Calmodulin-2; Calmodulin-3; CAM; CAM1; Cam2; CAM3; CAMB; Camc; CaMI; CaMII; CaMIII; LP7057 protein; LQT15; PHKD; PHKD2; phosphorylase kinase delta; phosphorylase kinase subunit delta; prepro-calmodulin 2
• Gene Symbols: CALM2
• Host Species: Rabbit
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-149 of human CALM2 (NP_001734.1).
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 12314, 805
• Target Species: Human, Mouse
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG