Thermo Scientific Chemicals Calpain Inhibitor II, 95+%

Catalog No.	Quantity
AAJ62491MB	25 mg

Catalog No. AAJ62491MB Supplier Thermo Scientific Chemicals Supplier No. J62491MB

Description

An inhibitor of calpains I and II

ALLM (Calpain Inhibitor) is a cell-permeable, peptide aldehyde inhibitor of calpain I and calpain II. ALLM acts as a very potent inhibitor of cathepsin L and the strongest inhibitor of cathepsin B amongst the peptide aldehydes. This compound inhibits the processing of malaria aspartic hemoglobinases plasmepsins I and II in vitro. ALLM also inhibits other neutral cysteine proteases, and activation-induced programmed cell death. It restores defective immune responses in HIV+ donors. ALLM blocks nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene. ALLM also acts as a weak inhibitor of proteasome.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Specifications

Chemical Identifiers

• CAS: 136632-32-1
• Molecular Formula: C₁₉H₃₅N₃O₄S, C19H35N3O4S
• Synonym: N-Ac-Leu-Leu-Methioninal; ALLM

• Quantity: 25 mg
• Description: White
• Content And Storage: -30°C to -10°C
• For Use With (Application): An inhibitor of calpains I and II
• Formula Weight: 401.60g/mol
• Solubility: Soluble in ethanol at 20mg/ml
• Product Type: Signal Transduction Reagent
• Form: Powder
• Beilstein: 7693643
• InChI Key: RJWLAIMXRBDUMH-UHFFFAOYNA-N
• SMILES: CSCCC(NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(C)=O)C=O
• IUPAC Name: 2-acetamido-4-methyl-N-(3-methyl-1-{[4-(methylsulfanyl)-1-oxobutan-2-yl]carbamoyl}butyl)pentanamide
• Molecular Weight (g/mol): 401.57
• Assay: ≥95%

Safety and Handling

Recommended Storage

Store at -20°C

SDS

RUO – Research Use Only