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Invitrogen™ CAPNS2 Polyclonal Antibody
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Catalog No. PIPA5103691
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PIPA5103691 100 μL
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Catalog No. PIPA5103691 Supplier Invitrogen™ Supplier No. PA5103691
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total CAPNS2.

The Calpain family of proteins are calcium-regulated thiol proteases which have broad endopeptidase activity throughout the body. Calpain small subunit 2, also known as CSS2 or CAPNS2, is a calcium-dependent protease that is expressed ubiquitously in the cytoplasm. Part of a heterodimer composed of a small subunit and a large subunit, CSS2 catalyzes proteolysis of various proteins involved in cytoskeletal remodeling and signal transduction. CSS2 also acts as a chaperone to the larger subunit, mediating its correct folding and conformation. When bound as a heterodimer, CSS2 is thought to keep the catalytic activity of the large subunit dormant. After binding calcium, CSS2 is released from the complex, thereby activating the large subunit and allowing CSS2 to translocate from the cytoplasm to the cell membrane. Defects in the gene encoding CSS2 result in incorrect calpain activity and retarded fetal development, suggesting that CSS2 expression is essential for proper growth.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CAPNS2
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene CAPNS2
Gene Accession No. Q96L46, Q9D7J7
Gene Alias 2310005G05Rik; 30K-2; calcium-dependent protease small subunit 2; Calpain small subunit 2; calpain, small subunit 2; CAPNS2; CSS2
Gene Symbols CAPNS2
Host Species Rabbit
Immunogen A synthesized peptide derived from human CAPNS2(Accession Q96L46), corresponding to amino acid residues G96-Y146.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 69543, 84290
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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