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Invitrogen™ Calpastatin Monoclonal Antibody (1F7E3D10)
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Catalog No. MA3944
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100 μL
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MA3944 100 μL
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Catalog No. MA3944 Supplier Invitrogen™ Supplier No. MA3944
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Description

Mouse Monoclonal Antibody

MA3-944 detects calpastatin from bovine, human, pig and rat tissues and cells. This antibody does not cross-react with calpains or calmodulin. MA3-944 has been successfully used in Western blot and immunocytochemical procedures. By Western blot, this antibody detects 150, 125, 90 and 70 kDa proteins from bovine skeletal muscle extract which have been suggested to be proteins translated from different start sites of the calpastatin gene. Immunocytochemical staining of calpastatin in porcine LLC-PK1 cells with MA3-944 results in diffuse cytoplasmic staining. The MA3-944 antigen is purified bovine skeletal muscle 80 kDa subunit of m-calpastatin. This antibody recognizes an epitope between amino acid residues 543-673 (domain IV) of human calpastatin.

Calpastatin is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It consists of an N-terminal domain L and four repetitive calpain-inhibition domains (domains 1-4), and it is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. The protein is also thought to affect the expression levels of genes encoding structural or regulatory proteins.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Calpastatin
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Monoclonal
Clone 1F7E3D10
Concentration Conc. Not Determined
Conjugate Unconjugated
Formulation ascites with 0.05% sodium azide
Gene Cast
Gene Accession No. P12675, P20810, P20811, P27321
Gene Alias BS-17; Calpain inhibitor; calpastatin; calpastatin isoform III; calpastatin precursor (EC 3.4.22.17); calpastatin type 1; calpastatin type 2; calpastatin type 3; calpastatin type I; calpastatin type II; calpastatin type III; calpastatin type IV; Cast; Erythrocyte calpastatin; heart calpastatin; PLACK; Sperm BS-17 component; type III calpastatin
Gene Symbols Cast
Host Species Mouse
Immunogen Purified bovine skeletal muscle 80 kDa subunit of m-Calpastatin.
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 25403, 281039, 397135, 831
Target Species Human, Rat, Bovine, Pig
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1
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