Invitrogen™ Calreticulin Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA3900

Catalog No. PA3900

Description

PA3-900 detects calreticulin from human, non-human primate, rabbit, mouse, canine and rat samples. PA3-900 has been successfully used in Western blot, immunofluorescence, immunocytochemistry, flow cytometry, and immunoprecipitation procedures. By Western blot, this antibody detects an ~60 kDa protein representing calreticulin from rat brain extract. Immunofluorescence staining of calreticulin in rat brain cortex with PA3-900 results in fine granular staining consistent with ER localization. PA3-900 immunogen is recombinant human calreticulin protein produced in the Baculovirus insect cell system.

Calr or Calreticulin is a calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. Calr, a lectin, interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Calr also interacts with with the DNA-binding domain of NR3C1 and mediates its nuclear export. It may also be involved in maternal gene expression regulation and oocyte maturation via the regulation of calcium homeostasis.

Specifications

• Antigen: Calreticulin
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CALR
• Gene Alias: Autoantigen RO; CABP3; CALBP; calcium-binding protein 3; CALR; calrectulin; calregulin; Calreticulin; calreticulin precursor; cC1qR; CRP55; CRT; CRTC; Endoplasmic reticulum resident protein 60; epididymis secretory sperm binding protein Li 99n; ERp60; FLJ26680; grp60; HACBP; HEL-S-99n; I79_008346; RO; Ro/SS-A Antigen; Sicca syndrome antigen A (autoantigen Ro; calreticulin); SSA
• Host Species: Rabbit
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat, Canine, Rabbit, Monkey
• Product Type: Antibody
• Isotype: IgG

• Applications: Flow Cytometry, Immunohistochemistry, Immunoprecipitation, Western Blot, Immunocytochemistry
• Concentration: Conc. Not Determined
• Formulation: Whole serum with 0.05% sodium azide
• Gene Accession No.: P14211, P15253, P18418, P27797, P28490
• Gene Symbols: CALR
• Immunogen: Recombinant, human calreticulin protein.
• Regulatory Status: RUO
• Gene ID (Entrez): 100009050, 100350417, 12317, 476694, 64202, 811
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid