Invitrogen™ Calsequestrin Recombinant Rabbit Monoclonal Antibody (JB57-37)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA534679

Catalog No. PIMA534679

Description

Positive Control: Rat skeletal muscle tissue, mouse skeletal muscle tissue, human fetal skeletal muscle tissue, C2C12.

The sarcoplasmic reticulum (SR) is, in part, responsible for maintaining the level of intracellular calcium in cardiac and skeletal muscle by storing and releasing calcium. Several intralumenal SR calcium binding proteins have been identified, the most prominent of these is calsequestrin. Calsequstrin is a calcium binding protein known to sequester calcium accumulated in the sarcoplasmic reticulum of muscle cells during relaxation and is found discretely localized to the junctional and corbular (terminal cisternae) SR. Calsequestrin functions to localize calcium near the junctional face of the terminal cisternae from which calcium can be released into the cytosol via the ryanodine receptor. This protein is highly acidic and has a large capacity and moderate to low affinity for calcium.

Specifications

• Antigen: Calsequestrin
• Classification: Recombinant Monoclonal
• Concentration: 1 mg/mL
• Formulation: TBS with 0.05% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
• Gene Accession No.: P31415
• Gene Symbols: CASQ1
• Immunogen: Recombinant protein within Human Calsequestrin 1 aa 80-220.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
• Clone: JB57-37
• Conjugate: Unconjugated
• Gene: CASQ1
• Gene Alias: Aspartactin; calmitin; calmitine; calsequestrin; calsequestrin 1; calsequestrin 1 (fast-twitch, skeletal muscle); calsequestrin, skeletal muscle isoform; Calsequestrin-1; calsquestrin 1; CASQ; Casq1; CSQ; CSQ1; CSQ-1; Laminin-binding protein; PDIB1; sCSQ; skeletal muscle calsequestrin 1; VMCQA
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 844
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles, store in dark
• Form: Liquid