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  6. 1336100U

Calyculin A, Tocris Bioscience™

Catalog No. 1336100U
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Quantity:
100 μg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Protein phosphatase 1 and 2A inhibitor

Calyculin A is a potent and selective cell-permeable inhibitor of protein phosphatase 1 (IC50 = 0.3 - 0.7 nM) and protein phosphatase 2A (IC50 = 0.5 - 1 nM). Displays > 10,000,000-fold selectivity over PP2B and PP2C.

Note: This product is typically prepared in DMSO.

Chemical Identifiers

CAS 101932-71-2
Molecular Formula C50H81N4O15P
Molecular Weight (g/mol) 1009.185
InChI Key FKAWLXNLHHIHLA-OROLNYDDSA-N
Synonym calyculin a
PubChem CID 131632568
IUPAC Name [(2R,3R,5R,7R,8R,9S)-2-[(1S,3S,4S,5R,6R)-14-cyano-3,5-dihydroxy-1-methoxy-4,6,8,9,13-pentamethyltetradeca-7,9,11,13-tetraenyl]-9-[3-[2-[(2S)-4-[[(2S,3S,4S)-4-(dimethylamino)-2,3-dihydroxy-5-methoxypentanoyl]amino]butan-2-yl]-1,3-oxazol-4-yl]prop-2-enyl]-7
SMILES CC1C(CC2(C(C(C(O2)C(CC(C(C)C(C(C)C=C(C)C(=CC=CC(=CC#N)C)C)O)O)OC)OP(=O)(O)O)(C)C)OC1CC=CC3=COC(=N3)C(C)CCNC(=O)C(C(C(COC)N(C)C)O)O)O

Specifications

Quantity 100 μg
Formula Weight 1009.18
Percent Purity >98%
Chemical Name or Material Calyculin A

Safety and Handling

Recommended Storage Desiccate at -20°C
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