Invitrogen™ cAMP Polyclonal Antibody

Catalog No.	Quantity
01-671-895	200 μL

Catalog No. 01-671-895 Supplier Invitrogen™ Supplier No. PA110840

Description

Sheep Polyclonal Antibody

PA1-10840 detects cAMP. PA1-10840 has been successfully used in ELISA applications. The PA1-10840 immunogen is Succinylated cAMP, conjugated to BSA.

Cyclic adenosine monophosphate (cAMP) plays a key role as an intracellular second messenger for transduction events that follow a number of extracellular signals. The G-Protein Coupled Receptors (GPCR) is the largest family of cell surface receptors. They can be activated by different ligands, such as neurotransmitters, hormones, ions, small molecules, peptides, and other physiological signaling molecules. Typically, the binding of the ligands to its receptor resulting in the activation of G-proteins, in return, activates the effector adenylyl cyclase evoking the production of cAMP. The activation of a protein kinase by cAMP results in the phosphorylation of substrate proteins. Currently successful drugs in marketing have been developed to target these receptors. Among the GPCRs, ~367 receptors are potential drug development targets, but only about 20 have been used to generate therapeutically and commercially successful drugs so far. Because the involvement of cAMP can amplify the response of the ligand binding, the second messenger cAMP has been largely employed to monitor the activation of the GPCR to facilitate the therapeutic drug discovery.

Specifications

• Antigen: cAMP
• Applications: ELISA
• Classification: Polyclonal
• Concentration: Conc. Not Determined
• Conjugate: Unconjugated
• Formulation: whole serum with 0.1% sodium azide
• Gene Alias: 18 kDa cationic antimicrobial protein; Antibacterial peptide FALL-39; Antibacterial peptide LL-37; CAMP; CAP18; CAP-18; Cathelicidin antimicrobial peptide; cathelin-like protein; Cathelin-related antimicrobial peptide; CLP; Cnlp; Cramp; Cyclic AMP; FALL39; FALL-39; FALL-39 peptide antibiotic; HSD26; LL37; MCLP
• Host Species: Sheep
• Immunogen: Succinylated cAMP, conjugated to BSA.
• Quantity: 200 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Chemical
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG
• Target Molecule: Chemical