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Invitrogen™ CAPNS2 Polyclonal Antibody
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Catalog No. PIPA584434
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100 μL
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PIPA584434 100 μL
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Catalog No. PIPA584434 Supplier Invitrogen™ Supplier No. PA584434
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: KWQCVYKQYD RDHSGSLGSS QLRGALQAAG FQLNEQLYQM IVRRYANEDG D Highest antigen sequence indentity to the following orthologs: Rat - 55%, Mouse - 86%.

The Calpain family of proteins are calcium-regulated thiol proteases which have broad endopeptidase activity throughout the body. Calpain small subunit 2, also known as CSS2 or CAPNS2, is a calcium-dependent protease that is expressed ubiquitously in the cytoplasm. Part of a heterodimer composed of a small subunit and a large subunit, CSS2 catalyzes proteolysis of various proteins involved in cytoskeletal remodeling and signal transduction. CSS2 also acts as a chaperone to the larger subunit, mediating its correct folding and conformation. When bound as a heterodimer, CSS2 is thought to keep the catalytic activity of the large subunit dormant. After binding calcium, CSS2 is released from the complex, thereby activating the large subunit and allowing CSS2 to translocate from the cytoplasm to the cell membrane. Defects in the gene encoding CSS2 result in incorrect calpain activity and retarded fetal development, suggesting that CSS2 expression is essential for proper growth.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CAPNS2
Applications Immunocytochemistry
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene CAPNS2
Gene Accession No. Q96L46
Gene Alias 2310005G05Rik; 30K-2; calcium-dependent protease small subunit 2; Calpain small subunit 2; calpain, small subunit 2; CAPNS2; CSS2
Gene Symbols CAPNS2
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human CAPNS2. Recombinant protein control fragment (Product #RP-108284).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 84290
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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