Cytiva Capto™ Core 400

Description

Designed for intermediate purification and polishing of viruses and other large biomolecules.

Novel core bead technology and multimodal ligand give Capto Core 400 dual functionality, size exclusion and binding chromatography, in one chromatography resin.

• Significantly improved productivity enabled by up to 100‐fold higher sample load and significantly higher flow rates compared with SEC.
• Bead with ligand‐activated core and inactive shell allows efficient capture of impurities, while target molecules are collected in the flowthrough.
• Straightforward optimization due to flow-through chromatography and robust performance, allowing for a wide window of operation.

Capto Core 400 is an excellent alternative to size‐exclusion chromatography (SEC) resins that are typically employed in the final stages of virus purification in vaccine manufacture.

Specifications

• Buffer: 1 M sodium hydroxide (NaOH), 6 M guanidine hydrochloride, 30% isopropanol, and 70% ethanol
• Final Product Type: Chromatography Resin
• Product Type: Agarose Chromatography Resin
• Bed Volume: 100 mL
• Protein Form: Virus
• Quantity: Each
• Height (Metric): 20 cm
• Flow Rate: 700 cm/hr.
• Material: Agarose
• Ligand Type: Octylamine
• pH Range: 3 to 14
• Particle Size: 90 μm
• Content And Storage: 4°C to 30°C
• Capacity: 22 mg
• Expression System: Virus
• Expression Competent Cell: Retrovirus
• Column Type: Tricorn Column
• Molecular Weight (g/mol): 400,000
• Matrix: Multimodal Resin