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Invitrogen™ Carbonic Anhydrase IX Polyclonal Antibody
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Catalog No. PIPA577885
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100 μL
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PIPA577885 100 μL
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Catalog No. PIPA577885 Supplier Invitrogen™ Supplier No. PA577885
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Description

Rabbit Polyclonal Antibody

Positive Control: HepG2 (untreated), HepG2 (200uM CoCl2 treatment for 24hr) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Carbonic anhydrase (CA) is an enzyme that assists rapid interconversion of carbon dioxide and water into carbonic acid, protons, and bicarbonate ions. It is abundant in all mammalian tissues. There are many genes that are inducible by hypoxia, via HIF-1 alpha. CA IX is one of the most inducible genes because of its stability and location within the membrane. Carbonic anhydrases have a widespread role in regulating pH in normal tissues, by regulating hydrogen ion (H+) flux. The pH is important in cell death under hypoxia, thus a blockade of CA IX results in increased cell death under hypoxia. Therefore, CA IX has become a reliable histochemical marker of hypoxia.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Carbonic Anhydrase IX
Applications Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.12 mg/mL
Conjugate Unconjugated
Formulation PBS with 20% glycerol, 1% BSA and 0.025% ProClin 300; pH 7
Gene CA9
Gene Accession No. Q16790, Q8VHB5
Gene Alias Ca9; CA-9; CAIX; CA-IX; Car9; Carbonate dehydratase IX; carbonic anhydrase 9; Carbonic anhydrase IX; carbonic dehydratase; G250; Membrane antigen MN; membrane antigen MN homolog; MN; MN/CA9; P54 / 58N; P54/58N; pMW1; RCC-associated antigen G250; RCC-associated protein G250; renal cell carcinoma-associated antigen G250
Gene Symbols CA9, Car9
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the Extracellular domain of human Carbonic Anhydrase IX. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 230099, 768
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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