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Invitrogen™ Carbonic Anhydrase IX Polyclonal Antibody
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Catalog No. APPA6592 Shop All Thermo Scientific Products
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APPA6592 100 μL
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Catalog No. APPA6592 Supplier Invitrogen™ Supplier No. PA116592
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Description

Rabbit Polyclonal Antibody

Suggested positive control: antigen standard for CA9 (transient overexpression lysate), Renal carcinoma.

Carbonic anhydrase (CA) is an enzyme that assists rapid interconversion of carbon dioxide and water into carbonic acid, protons, and bicarbonate ions. It is abundant in all mammalian tissues. There are many genes that are inducible by hypoxia, via HIF-1 alpha. CA IX is one of the most inducible genes because of its stability and location within the membrane. Carbonic anhydrases have a widespread role in regulating pH in normal tissues, by regulating hydrogen ion (H+) flux. The pH is important in cell death under hypoxia, thus a blockade of CA IX results in increased cell death under hypoxia. Therefore, CA IX has become a reliable histochemical marker of hypoxia.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Carbonic Anhydrase IX
Applications ChIP Assay, Flow Cytometry, Gel Shift, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), In Situ Hybridization (ISH), Western Blot, Proximity Ligation Assay, Immunocytochemistry
Classification Polyclonal
Concentration 1.0 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene CA9
Gene Accession No. Q16790, Q8VHB5
Gene Alias Ca9; CA-9; CAIX; CA-IX; Car9; Carbonate dehydratase IX; carbonic anhydrase 9; Carbonic anhydrase IX; carbonic dehydratase; G250; Membrane antigen MN; membrane antigen MN homolog; MN; MN/CA9; P54 / 58N; P54/58N; pMW1; RCC-associated antigen G250; RCC-associated protein G250; renal cell carcinoma-associated antigen G250
Gene Symbols CA9, Car9
Host Species Rabbit
Immunogen Synthetic peptide from the C-terminal sequence of human Carbonic Anhydrase IX (within residues 400-459).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 230099, 313495, 768
Target Species Human, Mouse, Rat, Plant
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer and Reproductive Harm - www.P65Warnings.ca.gov
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