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Invitrogen™ Carbonic Anhydrase IX Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA116592

Catalog No. APPA6592

  • $583.65 / Each of 1

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    Reg : $636.00

    The following deviations and disclosures may produce prices below stated discounts but will not trigger price reductions: Price shown reflects a temporary, promotional price reduction. No other purchase or commercial obligation required to receive the reduced price. Price may change at any time. Promotional price valid on web orders only. Your contract pricing may differ. Other exclusions apply.
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Description

Description

Suggested positive control: antigen standard for CA9 (transient overexpression lysate), Renal carcinoma.

Carbonic anhydrase (CA) is an enzyme that assists rapid interconversion of carbon dioxide and water into carbonic acid, protons, and bicarbonate ions. It is abundant in all mammalian tissues. There are many genes that are inducible by hypoxia, via HIF-1 alpha. CA IX is one of the most inducible genes because of its stability and location within the membrane. Carbonic anhydrases have a widespread role in regulating pH in normal tissues, by regulating hydrogen ion (H+) flux. The pH is important in cell death under hypoxia, thus a blockade of CA IX results in increased cell death under hypoxia. Therefore, CA IX has become a reliable histochemical marker of hypoxia.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

Carbonic Anhydrase IX
Polyclonal
Unconjugated
CA9
Ca9; CA-9; CAIX; CA-IX; Car9; Carbonate dehydratase IX; carbonic anhydrase 9; Carbonic anhydrase IX; carbonic dehydratase; G250; Membrane antigen MN; membrane antigen MN homolog; MN; MN/CA9; P54 / 58N; P54/58N; pMW1; RCC-associated antigen G250; RCC-associated protein G250; renal cell carcinoma-associated antigen G250
Rabbit
Antigen Affinity Chromatography
RUO
230099, 313495, 768
-20°C, Avoid Freeze/Thaw Cycles
Liquid
ChIP Assay, ELISA, Flow Cytometry, Gel Shift, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot, Proximity Ligation Assay, Immunocytochemistry
1.0 mg/mL
PBS with 0.02% sodium azide
Q16790, Q8VHB5
CA9, Car9
A synthetic peptide derived from a C-terminal sequence of the human CA IX.
100 μL
Primary
Human, Mouse, Rat, Plant
Antibody
IgG
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