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Invitrogen™ CASPASE 1 P10 (CLEAVED ALA317) Polyclonal Antibody
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Catalog No. PIPA5105049
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PIPA5105049 100 μL
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Catalog No. PIPA5105049 Supplier Invitrogen™ Supplier No. PA5105049
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of fragment of activated Caspase-1 resulting from cleavage adjacent to Ala317.

Caspase-1 (CASP1) is a thiol protease that cleaves IL-1 beta between Asp and Ala. This cleavage causes the release of the mature cytokine which is involved in a variety of inflammatory processes. CASP1 is important for defense against pathogen. It cleaves and activates sterol regulatory element binding proteins (SREBPs). CASP1 also promotes apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, CASP1 controls antiviral immunity through the cleavage of CGAS and renders it inactive.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CASPASE 1 P10 (CLEAVED ALA317)
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene CASP1
Gene Accession No. P29452, P29466, P43527
Gene Alias Casp1; CASP-1; CASP1 nirs variant 1; caspase 1; caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase); caspase-1; Caspase-1 subunit p10; Caspase-1 subunit p20; ICE; IL-1 beta-converting enzyme; IL-1B converting enzyme; IL1BC; IL-1BC; IL1BCE; IL1B-convertase; interleukin 1 beta-converting enzyme; interleukin 1, beta, convertase; interleukin 1-B converting enzyme; Interleukin 1beta converting enzyme; interleukin-1 beta convertase; Interleukin-1 beta-converting enzyme; p45
Gene Symbols CASP1
Host Species Rabbit
Immunogen A synthesized peptide derived from human CASP1(Accession P29466), corresponding to amino acid residues T310-S332.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12362, 25166, 834
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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