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Invitrogen™ Active/Pro-Caspase 3 Monoclonal Antibody (31A1067)
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Catalog No. MA191637
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100 μg
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MA191637 100 μg
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Catalog No. MA191637 Supplier Invitrogen™ Supplier No. MA191637
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Description

Mouse Monoclonal Antibody

Predicted molecular weight: 31kDa. Positive Control: Staurosporine-treated HeLa or Jurkat cell lysate.

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Active/Pro-Caspase 3
Applications Flow Cytometry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunomicroscopy, Western Blot, Immunocytochemistry, Mass Spectrometry
Classification Monoclonal
Clone 31A1067
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% sodium azide
Gene CASP3
Gene Accession No. P42574, P55213, P70677, Q95ND5
Gene Alias A830040C14Rik; AC-3; Apopain; Casp3; CASP-3; caspase 3; Caspase 3 apoptosis related cysteine protease (ICE-like cysteine protease); caspase 3, apoptosis related cysteine protease; Caspase 3, apoptosis related cysteine protease (ICE-like cysteine protease); caspase 3, apoptosis-related cysteine peptidase; caspase 3, apoptosis-related cysteine protease; caspase-3; Caspase-3 subunit p12; Caspase-3 subunit p17; CC3; Cpp32; CPP-32; CPP32B; CPP32beta; cysteine protease CPP32; IRP; Lice; mldy; PARP cleavage protease; procaspase3; protein Yama; SCA-1; SREBP cleavage activity 1; Yama; yama protein
Gene Symbols CASP3
Host Species Mouse
Immunogen Full-length recombinant human caspase-3 protein was used as immunogen. The antibody recognizes an epitope in the large domain subunit of Caspase-3. As such it will recognize pro Caspase-3 and the large subunit cleavage fragment.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100689061, 12367, 25402, 397244, 836
Target Species Hamster, Human, Mouse, Pig, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov
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