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AdipoGen anti-Caspase-8 (human), mAb (C15) (50 µg)
Supplier: AdipoGen AG20B0057C050
Monoclonal Antibody. Recognizes the p18 subunit of human caspase-8. Isotype: Mouse IgG2b. Clone: C15. Applications: ICC, IP, WB. Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. Procaspase-8 belongs to the family of caspases. Binding of FasL to Fas leads to formation of a receptor complex at the cellular membrane, which was named DISC. The DISC consists of oligomerized receptors, the DD-containing adaptor molecule FADD, procaspase-8, procaspase-10 and c-FLIP. The DISC structure provides a platform for the oligomerization of procaspase-8 that allows two procaspase-8 homodimers to be in the close proximity leading to the initial activation of procaspase-8. At the first cleavage step, the N-terminal p43/p41 and the C-terminal p30 cleavage products are generated. At the second cleavage step, p43/p41 and p30 are processed to p10 and p18, respectively, which leads to the generation of the active caspase-8 heterotetramer (p18/p10)2.
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