Invitrogen™ CASPR Monoclonal Antibody (A2D3)

Catalog No.	Quantity
PIMA536119	100 μL

Catalog No. PIMA536119 Supplier Invitrogen™ Supplier No. MA536119

Description

Mouse Monoclonal Antibody

CASPR Monoclonal Antibody for Flow, ICC/IF, IHC (P), Western Blot

CNTNAP1 was initially identified as a 190-kDa protein associated with the contactin-PTPRZ1 complex. The 1, 384-amino acid protein, also designated p190 or CASPR for 'contactin-associated protein, ' includes an extracellular domain with several putative protein-protein interaction domains, a putative transmembrane domain, and a 74-amino acid cytoplasmic domain. The architecture of its extracellular domain is similar to that of neurexins, and this protein may be the signaling subunit of contactin, enabling recruitment and activation of intracellular signaling pathways in neurons. The gene product was initially identified as a 190-kDa protein associated with the contactin-PTPRZ1 complex. The 1, 381-amino acid protein, also designated p190 or CASPR for 'contactin-associated protein, ' includes an extracellular domain with several putative protein-protein interaction domains, a putative transmembrane domain, and a 74-amino acid cytoplasmic domain. Northern blot analysis showed that the gene is transcribed predominantly in brain as a transcript of 6.2 kb, with weak expression in several other tissues tested. The architecture of its extracellular domain is similar to that of neurexins, and this protein may be the signaling subunit of contactin, enabling recruitment and activation of intracellular signaling pathways in neurons.

Specifications

• Antigen: CASPR
• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Classification: Monoclonal
• Clone: A2D3
• Concentration: 2 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.2% BSA, 50% glycerol and 0.05% sodium azide; pH 7.4
• Gene: Cntnap1
• Gene Accession No.: O54991, P78357
• Gene Alias: AI841080; Caspr; caspr1; CNTNAP; CNTNAP1; contactin associated protein 1; contactin associated protein-like 1; contactin-associated protein 1; LOW QUALITY PROTEIN: contactin-associated protein 1; MHDNIV; NCP1; neurexin 4; neurexin 4 (contactin associated protein); neurexin IV; Neurexin-4; NRXN4; p190; paranodin; shm
• Gene Symbols: Cntnap1
• Host Species: Mouse
• Immunogen: Recombinant protein within Human Caspr aa 1,108-1,303.
• Purification Method: Protein G
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 53321, 8506
• Target Species: Human, Mouse
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgM