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Invitrogen™ Cathepsin A Polyclonal Antibody
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Catalog No. PIPA5102793
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PIPA5102793 100 μL
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Catalog No. PIPA5102793 Supplier Invitrogen™ Supplier No. PA5102793
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total CTSA.

The cathepsin family of proteolytic enzymes include several diverse classes of proteases. Cathepsins B, L, H, K, S and O comprise the cysteine protease class. Cathepsins D and E comprise the aspartyle protease class. The serine protease class includes cathepsin G. Cathepsins function in cellular metabolism and participate in peptide biosynthesis and protein degradation. Cathepsin A, a serine carboxypeptidase, exists in a high molecular weight lysosomal complex with b-galactosidase (b-gal) and a-neuraminidase (Neu1). Cathepsin A functions to protect b-gal and Neu1 from intralysosomal proteolysis. Deficiencies in cathepsin A lead to deficiencies in b-gal and Neu1. The gene encoding human cathepsin A maps to chromosome 20q13.12. Mutations in this gene cause glactosialidosis, a lysosomal storage disorder resulting from the b-gal and Neu1 deficiencies.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Cathepsin A
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene CTSA
Gene Accession No. P10619, P16675
Gene Alias AU019505; beta-galactosidase 2; beta-galactosidase protective protein; carboxypeptidase C; Carboxypeptidase L; carboxypeptidase Y-like kininase; carboxypeptidase-L; cathepsin A; CTSA; deamidase; GLB2; GSL; lysosomal carboxypeptidase A; lysosomal protective protein; Lysosomal protective protein 20 kDa chain; Lysosomal protective protein 32 kDa chain; NGBE; PPCA; PPGB; protective protein cathepsin A; Protective protein for beta-galactosidase; urinary kininase
Gene Symbols CTSA
Host Species Rabbit
Immunogen A synthesized peptide derived from human CTSA(Accession P10619), corresponding to amino acid residues L394-F444.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 19025, 296370, 5476
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

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