Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Antibodies
  4. Primary Antibodies
  5. All Primary Antibodies
  6. PIMA545387

Invitrogen™ CaV1.2 Monoclonal Antibody (S57), APC
GREENER_CHOICE

Catalog No. PIMA545387
Change view
Click to view available options
Quantity:
100 μg
Catalog No. Quantity
PIMA545387 100 μg
1 options
This item is not returnable. View return policy

Catalog No. PIMA545387

Supplier: Invitrogen™ MA545387

Only null left
Add to Cart
Add to Cart
This item is not returnable. View return policy

Description

Mouse Monoclonal Antibody

1 μg/mL of MA5-45387 was sufficient for detection of Cav1.2 in 10 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. Detects approximately 240kDa (varies with cell background due to glycosylation).

CACNA1C encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by CACNA1C binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CaV1.2
Applications Immunohistochemistry (PFA fixed), Immunoprecipitation, Western Blot, Immunocytochemistry, Microarray
Classification Monoclonal
Clone S57
Concentration 1 mg/mL
Conjugate APC
Formulation 2.48mM MES, 95.64mM phosphate with 0.5M EDTA and no preservative; pH 7.4
Gene CACNA1C
Gene Accession No. P22002, Q01815, Q13936
Gene Alias brain class C; CACB; CaCB receptor; CACB-receptor; CACH2; CACH2C; CACH3; Cacn2; CACN4; CACNA 1D; Cacna1c; CACNL1A1; CACNL1A2; calcium channel; calcium channel voltage-dependent alpha1c subunit; calcium channel, cardic dihydropyridine-sensitive, alpha-1 subunit; calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle; calcium channel, voltage-dependent, alpha 1C subunit; calcium channel, voltage-dependent, L type, alpha 1C subunit; calcium voltage-gated channel subunit alpha1 C; cardiac L-type calcium channel; Cav1.2; CCHL1A1; D930026N18Rik; DHP receptor; DHPR, alpha-1 subunit; I79_006562; long-NT; LQT8; LTCC; L-type calcium channel alpha-1 subunit; MBC; MELC-CC; MGC120730; Mouse brain class C; neuronal voltage-gated calcium channel alpha 1C subunit; Rat brain class C; RATIVS302; RBC; skeletal muscle-specific calcium channel; smooth muscle calcium channel blocker; Smooth muscle calcium channel blocker receptor; TS; unnamed protein product; voltage-dependent L-type Ca2+ channel alpha 1 subunit; Voltage-dependent L-type calcium channel subunit alpha-1C; Voltage-gated calcium channel subunit alpha Cav1.2; voltage-gated L-type calcium channel Cav1.2 alpha 1 subunit, splice variant 10*
Gene Symbols CACNA1C
Host Species Mouse
Immunogen Fusion protein amino acids 1507-1733 (intracellular carboxyl terminus) of rabbit Cav1.2.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100754788, 12288, 24239, 775
Target Species Human, Mouse, Rat, Hamster
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG1
Show More Show Less

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.