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Invitrogen™ CaV3.2 Monoclonal Antibody (N55/10), FITC
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Catalog No. PIMA545396
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Quantity:
100 μg
Catalog No. Quantity
PIMA545396 100 μg
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Catalog No. PIMA545396

Supplier: Invitrogen™ MA545396

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Description

Mouse Monoclonal Antibody

1 μg/mL of MA5-45396 was sufficient for detection of Cav3.2 in 10 μg of HEK cell lysate expressing Cav3.2 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. Detects approximately 260kDa. No cross-reactivity against Cav1.3.

This gene encodes a T-type member of the alpha-1 subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. The alpha-1 subunit has 24 transmembrane segments and forms the pore through which ions pass into the cell. There are multiple isoforms of each of the proteins in the complex, either encoded by different genes or the result of alternative splicing of transcripts. Alternate transcriptional splice variants, encoding different isoforms, have been characterized for the gene described here. Studies suggest certain mutations in this gene lead to childhood absence epilepsy (CAE).
TRUSTED_SUSTAINABILITY

Specifications

Antigen CaV3.2
Applications Immunohistochemistry (Paraffin), Immunohistochemistry (PFA fixed), Immunoprecipitation, Western Blot, Immunocytochemistry, Microarray
Classification Monoclonal
Clone N55/10
Concentration 1 mg/mL
Conjugate FITC
Formulation PBS, 9.09mM sodium bicarbonate with 640.91mM DMSO, 136.36mM ethanolamine and no preservative; pH 7.4
Gene CACNA1H
Gene Accession No. O88427, O95180, Q9EQ60
Gene Alias A1H-b; alpha13.2; CACNA1H; CACNA1HB; calcium channel alpha13.2 subunit; calcium channel, voltage-dependent, T type, alpha 1H subunit; calcium channel, voltage-dependent, T type, alpha 1Hb subunit; calcium voltage-gated channel subunit alpha1 H; Cav3.2; ECA6; EIG6; FLJ90484; Low-voltage-activated calcium channel alpha1 3.2 subunit; low-voltage-activated calcium channel alpha13.2 subunit; MNCb-1209; T-type Cav3.2; voltage dependent t-type calcium channel alpha-1H subunit; voltage-dependent T-type calcium channel subunit alpha-1H; voltage-gated calcium channel alpha subunit Cav3.2; voltage-gated calcium channel alpha subunit CavT.2; voltage-gated calcium channel subunit alpha Cav3.2
Gene Symbols CACNA1H
Host Species Mouse
Immunogen Fusion protein amino acids 1019-1293 (II-III loop) of human Cav3.2.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 114862, 58226, 8912
Target Species Human, Mouse, Rat
Content And Storage 4°C, store in dark
Product Type Antibody
Form Liquid
Isotype IgG1
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