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Invitrogen™ Caveolin 2 Polyclonal Antibody
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Catalog No. PA1065
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100 μg
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PA1065 100 μg
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Catalog No. PA1065 Supplier Invitrogen™ Supplier No. PA1065
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Description

Rabbit Polyclonal Antibody

PA1-065 detects caveolin-2 from rat and mouse tissues tissues. This antibody does not detect caveolin-1 or -3. PA1-065 has been successfully used in Western blot and immunoprecipitation procedures. By Western blot, this antibody detects a ~21 kDa protein representing caveolin-2 from rat heart homogenate. The PA1-065 immunogen is a synthetic peptide corresponding to residues M(1) G L E T E K A D V Q L F M A D D A Y(19) C of rat CAV2. This sequence is completely conserved in mouse, and ~90% conserved in human caveolin-2. The PA1-065 immunizing peptide (Cat. # PEP-080) is available for use in neutralization and control experiments.

Caveolae are specialized domains of the plasma membrane that are implicated in the sequestration of a variety of lipid and protein molecules. It has been suggested that these important cellular organelles have a pivotal role in such diverse biochemical processes as lipid metabolism, growth regulation, signal transduction, and apoptosis. Caveolin interacts with and regulates heterotrimeric G-proteins. Currently, there are three members of the caveolin multigene family which are known to encode 21-24 kDa integral membrane proteins that comprise the major structural component of the caveolar membrane in vivo. Caveolin-2 protein is abundantly expressed in fibroblasts and differentiated adipocytes, smooth and skeletal muscle, and endothelial cells. The expression of caveolin-1 is similar to that of caveolin-2 while caveolin-3 expression appears to be limited to muscle tissue types.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Caveolin 2
Applications Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1 mg/mL BSA and 0.05% sodium azide
Gene CAV2
Gene Accession No. Q2IBC5, Q9WVC3
Gene Alias AI447843; CAV; CAV2; caveolae; caveolae protein, 20-kD; caveolin 2; caveolin 2 isoform a and b; caveolin-2; MGC12294; Phospho-CAV2
Gene Symbols CAV2
Host Species Rabbit
Immunogen Synthetic peptide corresponding to residues M(1) G L E T E K A D V Q L F M A D D A Y(19) C of rat CAV2.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12390, 363425
Target Species Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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