Invitrogen™ Caveolin 3 Recombinant Rabbit Monoclonal Antibody (SY22-06)

Catalog No.	Quantity
PIMA532084	100 μL

Catalog No. PIMA532084

Supplier: Invitrogen™ MA532084

Description

Rabbit Recombinant Monoclonal Antibody

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Caveolin-3 (CAV3) acts as a scaffolding protein within the caveolar membrane. It interacts directly with G-protein alpha subunits and can functionally regulate their activity. Caveolin-3 may also regulate voltage-gated potassium channels. It also plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress. Caveolin-3 also mediates the recruitment of CAVIN2 and CAVIN3 proteins to the caveolae. Mutations in the gene can result in HyperCKmia, rippling muscle disease 2, cardiomyopathy, long QT syndrome 9, sudden infant death syndrome, and myopathy.

Specifications

• Antigen: Caveolin 3
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Classification: Recombinant Monoclonal
• Clone: SY22-06
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: TBS with 40% Glycerol, 0.05% BSA and 0.05% sodium azide; pH 7.4
• Gene: Cav3
• Gene Accession No.: P51637, P51638, P56539
• Gene Alias: AI385751; CAV; Cav3; Cav-3; caveolin 3; caveolin-3; LGMD1C; LQT9; M-cav; M-caveolin; MGC126100; MGC126101; MGC126129; structural protein; VIP21; VIP-21
• Gene Symbols: Cav3
• Host Species: Rabbit
• Immunogen: Recombinant protein within Human Caveolin-3 aa 1-125.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 12391, 29161, 859
• Target Species: Human, Mouse, Rat
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG