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  6. Invitrogen™ CCL4 (MIP-1 beta) Monoclonal Antibody (FL34Z3L), Alexa Fluor™ 488, eBioscience™, Invitrogen™ 

Invitrogen™ CCL4 (MIP-1 beta) Monoclonal Antibody (FL34Z3L), Alexa Fluor™ 488, eBioscience™, Invitrogen™
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Catalog No. 53754042
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100 Tests
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Catalog No. Quantity
53-754-042 100 Tests
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Catalog No. 53-754-042 Supplier Invitrogen™ Supplier No. 53754042
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Description

Mouse Monoclonal Antibody

CCL4 (macrophage inflammatory protein 1-beta, MIP1B) belongs to the intercrine beta (chemokine CC) family. Functionally, CCL4 is involved in chemotactic and proinflammatory effects, and homeostasis. CCL4 is produced by macrophages upon stimulation by bacterial endotoxins. CCL4 recruits and stimulates various inflammatory cells at sites of inflammation. CCL4 is produced by lymphocytes, macrophages and dendritic cells. Both CCL4 and the related protein CCL3 participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells. While both CCL4 and CCL3 exert similar effects on monocytes, their effect on lymphocytes differ, with CCL4 selectively attracting CD4+ lymphocytes and CCL3 selectively attracting CD8+ lymphocytes. Additionally, both have been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. The processed form of CCL4 can induce down-modulation of surface expression of the chemokine receptor CCR5, thus inhibiting the CCR5-mediated entry of HIV-1 in T cells. CCL4 binds with high affinity to CCR5 receptors.
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Specifications

Antigen CCL4 (MIP-1 beta)
Applications Flow Cytometry
Classification Monoclonal
Clone FL34Z3L
Concentration 5 μL/Test
Conjugate Alexa Fluor 488
Formulation PBS with BSA and 0.09% sodium azide; pH 7.2
Gene CCL4
Gene Accession No. P13236
Gene Alias ACT2; ACT-2; AT744.1; CC chemokine ligand 4; C-C motif chemokine 4; C-C motif chemokine ligand 4; Ccl4; chemokine (C-C motif) ligand 4; G-26; G-26 T-lymphocyte-secreted protein; HC21; immune activation gene 2; immune activation gene-2; immune activation protein 2; LAG1; LAG-1; Lymphocyte activation gene 1 protein; macrophage inflammatory protein 1-beta; macrophage inflammatory protein-1 beta; MGC104418; MGC126025; MGC126026; MIP-1 beta; MIP1b; MIP-1B; Mip1-b; MIP1B1; MIP1beta; MIP-1BETA; MIP-1-beta; MIP1-beta; MIP-1-beta(1-69); MIP-1-beta(3-69); PAT 744; Protein H400; putative MIP-1beta protein; RP23-320E6.8; SCY4A; SCYA2; Scya4; secreted protein G-26; SIS-gamma; small inducible cytokine A4; small inducible cytokine A4 (homologous to mouse Mip-1b); small-inducible cytokine A4; T-cell activation protein 2
Gene Symbols CCL4
Host Species Mouse
Immunogen Recombinant Human CCL4.
Purification Method Affinity chromatography
Quantity 100 Tests
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6351
Target Species Human
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Liquid
Isotype IgG2a κ
Product Line eBioscience
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