Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Antibodies
  4. Primary Antibodies
  5. All Primary Antibodies
  6. PIPA523037

Invitrogen™ CCR2 Polyclonal Antibody
GREENER_CHOICE

Catalog No. PIPA523037
Change view
Click to view available options
Quantity:
100 μL
1 product options available for selection
Product selection table with 1 available options. Use arrow keys to navigate and Enter or Space to select.
Catalog No. Quantity
PIPA523037 100 μL
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 1 options available.
1 options
Catalog No. PIPA523037 Supplier Invitrogen™ Supplier No. PA523037
Only null left
Add to Cart
Add to Cart

Description

Rabbit Polyclonal Antibody

The immunogen sequence similarity with other species: Rhesus monkey and several other primate species (100%), Mouse (69%).

CCR2, a chemokine receptor, is a regulator of monocyte/macrophage traffickings and is upregulated in response to inflammation. Resistance to HIV-1 infection or delayed progression to AIDS may be linked to CCR2 polymorphisms. The ligand for CCR2 is monocyte chemoattractant protein (MCP-1), a chemokine produced by endothelial cells, smooth muscle cells, and macrophages. Activation of monocytes by MCP-1 may mediate the monocytic infiltration of tissues in atherosclerosis and other inflammatory disorders including rheumatoid arthritis, alveolitis, and tumor infiltration. Two isoforms are produced by alternative splicing. CCR2 has been reported to be expressed in a wide variety of tissues, including blood, brain, heart, kidney, liver, lung, ovary, pancreas, spinal cord, spleen, thymus, and vessel. Increased expression of CCR2 has been documented in CD3+ lymphocytes in rheumatoid arthritis. ESTs have been isolated from liver/spleen and prostate libraries.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CCR2
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene Ccr2
Gene Accession No. O55193, P41597
Gene Alias C-C chemokine receptor type 2; C-C CHEMOKINE RECEPTOR TYPE 2 (C-C CKR-2) (CC-CKR-2) (CCR-2) (CCR2) (JE/FIC RECEPTOR) (MCP-1 RECEPTOR); C-C CKR-2; C-C motif chemokine receptor 2; Cc-ckr2; CC-CKR-2; Ccr2; CCR-2; Ccr2a; CCR2B; CD192; CD192 antigen; chemoattractant protein-1 receptor; chemokine (C-C motif) receptor 2; chemokine (C-C) receptor 2; chemokine receptor CCR2; Ckr2; Ckr2a; Ckr2b; CMKBR2; hCG_14621; JE/FIC receptor; Mcp1 receptor; MCP-1 receptor; Mcp1r; MCP-1-R; MIP-1 alphaR; mJe-r; Monocyte chemoattractant protein 1 receptor; monocyte chemotactic protein 1 receptor
Gene Symbols Ccr2
Host Species Rabbit
Immunogen Synthetic peptide made to an N-terminal portion of the human CCR2 protein (within residues 20-100).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100049057, 539002, 60463, 729230
Target Species Human, Rat, Bovine, Feline
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
Show More Show Less

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.