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Tocris Bioscience™ CCT 241533 dihydrochloride
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Quantity:
10 mg
Description
CCT 241533 dihydrochloride is a potent Chk2 inhibitor (IC50 = 3 nM). Shows >63-fold selectivity for Chk1 over Chk2 and a panel of 84 other kinases. Inhibits Chk2 activation in response to etoposide -induced DNA damage in HT29 cells. Blocks ionizing radiation-induced apoptosis of mouse thymocytes.
Specifications
Specifications
Chemical Name or Material | (3R,4S)-4-[[2-(5-Fluoro-2-hydroxyphenyl)-6,7-dimethoxy-4-quinazolinyl]amino]-α,α-dimethyl-3-pyrrolidinemethanol dihydrochloride |
CAS | 1962925-28-5 |
Quantity | 10 mg |
Target | Checkpoint Kinase Inhibitors |
Molecular Formula | C23H27FN4O4.2HCl |
Formula Weight | 515.41 |
Purity | >98% |
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