Tocris Bioscience CCT 241533 dihydrochloride
Potent Chk2 inhibitor
Manufacturer: Tocris Bioscience 4968/10
DescriptionPotent Chk2 inhibitor (IC50 = 3 nM). Shows >63-fold selectivity for Chk1 over Chk2 and a panel of 84 other kinases. Inhibits Chk2 activation in response to etoposide -induced DNA damage in HT29 cells. Blocks ionizing radiation-induced apoptosis of mouse thymocytes.
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