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Tocris Bioscience™ CCT 241533 dihydrochloride

Catalog No. 496810
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Quantity:
10 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Potent Chk2 inhibitor

CCT 241533 dihydrochloride is a potent Chk2 inhibitor (IC50 = 3 nM). Shows >63-fold selectivity for Chk1 over Chk2 and a panel of 84 other kinases. Inhibits Chk2 activation in response to etoposide -induced DNA damage in HT29 cells. Blocks ionizing radiation-induced apoptosis of mouse thymocytes.

Specifications

Chemical Name or Material (3R,4S)-4-[[2-(5-Fluoro-2-hydroxyphenyl)-6,7-dimethoxy-4-quinazolinyl]amino]-α,α-dimethyl-3-pyrrolidinemethanol dihydrochloride
CAS 1962925-28-5
Quantity 10 mg
Target Checkpoint Kinase Inhibitors
Molecular Formula C23H27FN4O4.2HCl
Formula Weight 515.41
Purity >98%
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