Tocris Bioscience™ CCT 241533 dihydrochloride 

Potent Chk2 inhibitor

Manufacturer:  Tocris Bioscience™ 4968/10

Catalog No. 496810

Description

Potent Chk2 inhibitor (IC50 = 3 nM). Shows >63-fold selectivity for Chk1 over Chk2 and a panel of 84 other kinases. Inhibits Chk2 activation in response to etoposide -induced DNA damage in HT29 cells. Blocks ionizing radiation-induced apoptosis of mouse thymocytes.

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Specifications

• Chemical Name or Material: (3R,4S)-4-[[2-(5-Fluoro-2-hydroxyphenyl)-6,7-dimethoxy-4-quinazolinyl]amino]-α,α-dimethyl-3-pyrrolidinemethanol dihydrochloride
• Molecular Formula: C₂₃H₂₇FN₄O₄.2HCl
• Quantity: 10mg
• Purity: >98%

• CAS: 1962925-28-5
• Formula Weight: 515.41
• Product Type: Target: Checkpoint Kinase Inhibitors

Safety and Handling

Recommended Storage : Desiccate at RT