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  6. Invitrogen™ CD102 (ICAM-2) Monoclonal Antibody (3C4 (mIC2/4)), Functional Grade, eBioscience™, Invitrogen™ 

Invitrogen™ CD102 (ICAM-2) Monoclonal Antibody (3C4 (mIC2/4)), Functional Grade, eBioscience™, Invitrogen™
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Catalog No. 16102182
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Catalog No. 16-102-182 Supplier Invitrogen™ Supplier No. 16102182
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Description

Rat Monoclonal Antibody

Description: The monoclonal antibody 3C4 (mIC2/4) recognizes mouse CD102, also known as intercellular adhesion molecule-2 (ICAM-2). CD102, a member of the Immunoglobulin superfamily of receptors with 2 extracellular Ig domains, binds LFA (CD11a/CD18) and Mac-1 (CD11b/CD18), thereby mediating cellular interactions to lymphocytes. CD102 plays a role in NK cytotoxicity and migration, and lymphocyte recirculation. Expression of CD102 is found on most lymphocytes, monocytes and platelets. The 3C4 (mIC2/4) antibody blocks interaction of lymphocytes with antigen presenting cells. Applications Reported: This 3C4 (mIC2/4) antibody has been reported for use in flow cytometric analysis and functional assays. Applications Tested: This 3C4 (mIC2/4) antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 0.25 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Storage and handling: Use in a sterile environment. Filtration: 0.2 μm post-manufacturing filtered. Purity: Greater than 90%, as determined by SDS-PAGE. Endotoxin Level: Less than 0.001 ng/μg antibody, as determined by LAL assay. Aggregation: Less than 10%, as determined by HPLC.

ICAM-2 is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. ICAM-2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance. Several transcript variants encoding the same protein have been found for this gene. Diseases associated with ICAM2 include Colon Carcinoma In Situ.
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Specifications

Antigen CD102 (ICAM-2)
Applications Flow Cytometry, Functional Assay
Classification Monoclonal
Clone 3C4 (mIC2/4)
Concentration 1 mg/mL
Conjugate Functional Grade
Formulation PBS with no preservative; pH 7.2
Gene ICAM2
Gene Accession No. P35330
Gene Alias CD102; Icam2; ICAM-2; Intercellular adhesion molecule 2; Ly-60; Lymphocyte function-associated AG-1 counter-receptor; RP23-418O11.10-001
Gene Symbols ICAM2
Host Species Rat
Purification Method Affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 15896
Target Species Mouse
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG2a κ
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Safety and Handling

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