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Invitrogen™ CD102 (ICAM-2) Monoclonal Antibody (CBR-IC2/2), FITC, eBioscience™
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Catalog No. 11102942
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100 Tests
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Catalog No. Quantity
11-102-942 100 Tests
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Catalog No. 11-102-942 Supplier Invitrogen™ Supplier No. 11102942
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Description

Mouse Monoclonal Antibody

Description: The CBRIC2/2 monoclonal antibody reacts with human ICAM-2 (CD102). ICAM-2 is a 55-65 kD transmembrane glycoprotein possessing 2 extracellular Ig domains, a single transmembrane domain, and a short 26-amino acid cytoplasmic domain. ICAM-2 is expressed on most leukocytes, and is strongly expressed on vascular endothelial cells. ICAM-2 is a ligand of integrin CD11a/CD18 (LFA-1), and also has been reported to bind integrin CD11b/CD18 (Mac-1). ICAM-2 is an intercellular adhesion molecule involved in lymphocyte homing to sites of inflammation. The CBRIC2/2 antibody has been reported to have blocking activity. Applications Reported: This CBRIC2/2 antibody has been reported for use in flow cytometric analysis. Applications Tested: This CBRIC2/2 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at 5 μL (0.5 μg) per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser. Filtration: 0.2 μm post-manufacturing filtered.

ICAM-2 is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. ICAM-2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance. Several transcript variants encoding the same protein have been found for this gene. Diseases associated with ICAM2 include Colon Carcinoma In Situ.
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Specifications

Antigen CD102 (ICAM-2)
Applications Flow Cytometry
Classification Monoclonal
Clone CBR-IC2/2
Concentration 5 μL/Test
Conjugate FITC
Formulation PBS with BSA and 0.09% sodium azide; pH 7.2
Gene ICAM2
Gene Accession No. P13598
Gene Alias CD102; Icam2; ICAM-2; Intercellular adhesion molecule 2; Ly-60; Lymphocyte function-associated AG-1 counter-receptor; RP23-418O11.10-001
Gene Symbols ICAM2
Host Species Mouse
Purification Method Affinity chromatography
Quantity 100 Tests
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3384
Target Species Human
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Liquid
Isotype IgG2a
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