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Invitrogen™ CD105 Monoclonal Antibody (MEM-226), Alexa Fluor™ 488
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Catalog No. PIMA518120
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100 Tests
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PIMA518120 100 Tests
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Catalog No. PIMA518120 Supplier Invitrogen™ Supplier No. MA518120
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Description

Mouse Monoclonal Antibody

This antibody reacts with an extracellular epitope of CD105 (Endoglin), a 90 kDa type I homodimerizing membrane glycoprotein expressed on vascular endothelial cells (small and large vessels), activated monocytes and tissue macrophages, stromal cells of certain tissues including bone marrow, pre-B lymphocytes in fetal marrow and erythroid precursors in fetal and adult bone marrow; it is also present on syncytiotrophoblast on placenta throughout pregnancy.

CD105 or Endoglin is a Type I transmembrane protein, which is highly expressed on human vascular endothelial cells. It exists on an O- and N-glycosylated homodimer. Up regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation associated endothelial marker. CD105 binds to TGF beta 1 and 3 with high affinity but not to TGF beta 2.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD105
Applications Flow Cytometry, Western Blot
Classification Monoclonal
Clone MEM-226
Concentration 0.055 mg/mL
Conjugate Alexa Fluor 488
Formulation PBS with 0.2% BSA and 15mM sodium azide
Gene ENG
Gene Accession No. P17813
Gene Alias AI528660; AI662476; CD105; CD105 antigen; cell surface MJ7/18 antigen; Edg; END; Endo; Endoglin; endoglin (Osler-Rendu-Weber syndrome 1); Eng; HHT1; ORW; ORW1; S-endoglin; transmembrane glycoprotein
Gene Symbols ENG
Host Species Mouse
Immunogen Recombinant Vaccinia virus containing the human CD105 cDNA.
Purification Method Size-exclusion chromatography
Quantity 100 Tests
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2022, 497010
Target Species Human, Rat
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Liquid
Isotype IgG2a
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