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  6. BD Horizon™ CD105 Mouse, anti-Human, RY586, Clone: 266, BD Horizon™

BD Horizon™ CD105 Mouse, anti-Human, RY586, Clone: 266, BD Horizon™

Catalog No. p-7225551 Shop All BD Biosciences Products
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BDB568142 25 Tests
BDB568141 100 Tests
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Catalog No. BDB568142 Supplier BD Horizon™ Supplier No. 568142
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Description

Mouse Monoclonal Antibody

The 266 monoclonal antibody specifically binds to CD105. CD105 is a type I transmembrane glycoprotein that is encoded by END (Endoglin) and belongs to the transforming growth factor-β (TGF-β) type III receptor family. CD105 is expressed on cells as a homodimer comprised of ∼95 kDa subunits. CD105 is expressed on vascular endothelial cells and placental syncytiotrophoblasts and at lower levels on stromal fibroblasts. It is also expressed on mesenchymal stem cells, erythroid precursors, activated macrophages, pre-B cells, and some tumor cells and cell lines including U937 cells. CD105 serves as a regulatory component of the TGF-β receptor system. In association with TGF- βRI or TGF- βRII, CD105 binds TGF-β1 and TGF-β3 with high affinity but does not bind to TGF-β2. Expression of CD105 is increased on activated endothelium in tissues undergoing angiogenesis, such as in tumors, or in cases of wound healing or dermal inflammation.

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD105
Applications Flow Cytometry
Clone 266
Conjugate RY586
Host Species Mouse
Quantity 25 Tests
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human

Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov
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