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Invitrogen™ CD11c Monoclonal Antibody (118/A5), eBioscience™, Invitrogen™

Catalog No. 14976180
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25 μg
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14-976-180 25 μg
14-976-137 2 mg
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Catalog No. 14-976-180 Supplier Invitrogen™ Supplier No. 14976180
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Description

Mouse Monoclonal Antibody

The MAb 118/A5 recognizes human CD11c, a 150 kD type I transmembrane protein which is also known as integrin alpha X. Integrins are heterodimeric integral membrane proteins made up of an alpha and a beta chain and are involved in cell adhesion. The CD11/CD18 adhesion molecules consist of three heterodimers sharing a common beta subunit (CD18) with a distinct alpha subunit (CD11a, CD11b, CD11c). The CD11c/CD18 complex is expressed on dendritic cells (highly expressed on type 1 myeloid DCs), monocytes, macrophages, granulocytes, NK cells, and subsets of T and B cells. CD11c is also expressed in hairy cell leukemias, acute nonlymphocytic leukemias, and some B-cell chronic lymphocytic leukemias. CD11c plays a role in adhesion and CTL killing through its interactions with CD54, iC3b and fibrinogen.

CD11, along with CD18, form a heterodimer adhesion molecule. In particular, CD11 is composed of CD11a, CD11b and CD11c. CD11a is a leukocyte marker that is expressed in B and T lymphocytes, macrophages, monocytes, neutrophils, basophils and eosinophils. CD11b is primarily expressed by monocytes, macrophages, natural killer cells, some B and T-cells, and granulocytes. CD11c is expressed in monocytes, macrophages, natural killer cells, some granulocytes and less so in a subset of lymphocytes.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD11c
Applications Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone 118/A5
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide; pH 7.2
Gene Itgax
Gene Accession No. P20702
Gene Alias AI449405; CD11 antigen-like family member C; CD11c; CD11C (p150) alpha polypeptide; complement component 3 receptor 4 subunit; complement receptor 4; Cr4; integrin alpha X; integrin alpha-X; integrin aX; integrin subunit alpha X; integrin, alpha X; integrin, alpha X (antigen CD11C (p150), alpha polypeptide); integrin, alpha X (complement component 3 receptor 4 subunit); Itgax; Leu M5; leu M5, alpha subunit; leukocyte adhesion glycoprotein p150,95 alpha chain; Leukocyte adhesion receptor p150,95; leukocyte surface antigen p150,95, alpha subunit; myeloid membrane antigen, alpha subunit; N418; p150 95 integrin alpha chain; RGD1561123; SLEB6
Gene Symbols Itgax
Host Species Mouse
Purification Method Affinity chromatography
Quantity 25 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3687
Target Species Human
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG2b κ
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Safety and Handling

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