Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

CD134 (OX40) Rat anti-Mouse, Clone: OX-86, eBioscience™ Non-distribution product as customer accommodation.

Rat Monoclonal Antibody

$97.50 - $269.00

Specifications

Antigen CD134 (OX40)
Clone OX-86
Target Species Mouse
Conjugate Unconjugated
Isotype IgG1, kappa
View More Specs

Products 3
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
50-128-71 Non-distribution product as customer accommodation.
View Documents
Invitrogen
14134182
100 μg Each for $150.00
Add to cart
 
50-128-70 Non-distribution product as customer accommodation.
View Documents
Invitrogen
14134181
50 μg Each for $97.50
Add to cart
 
50-128-72 Non-distribution product as customer accommodation.
View Documents
Invitrogen
14134185
500 μg Each for $269.00
Add to cart
 
Description

Description

Description: The OX-86 monoclonal antibody reacts with mouse CD134, also known as OX40. A member of the TNF receptor superfamily, CD134 is a 50 kDa type I membrane glycoprotein expressed by activated mouse T lymphocytes. Rat CD134 was initially identified as an activation marker only on activated CD4+ T cells. In contrast, mouse CD134 is expressed by both activated CD4+ and CD8+ T cells. The interaction of CD134 with CD252 (OX40 ligand) has been implicated in T cell-dependent humoral responses, regulation of primary T cell expansion, survival of T cells, size of the memory T cell pool, and regulation of tolerance in the CD4+ T cell compartment. Applications Reported: The OX-86 antibody has been reported for use in flow cytometric analysis, immunoblotting (WB), and immunohistochemical staining of frozen tissue sections. It does not block binding of CD134 to its ligand, but has been reported for use in functional assays. Please use Functional Grade purified OX-86 in functional assays. Applications Tested: The OX-86 antibody has been tested by flow cytometric analysis of activated mouse splenocytes. This can be used at less than or equal to 0.5 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.

It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Purity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 µm post-manufacturing filtered. The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation.
Specifications

Specifications

CD134 (OX40)
Mouse
IgG1, kappa
Monoclonal
Liquid
Antibody
4° C
OX-86
Unconjugated
Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen), Neutralization, Western Blot
Primary
Monoclonal
PBS with 0.09% sodium azide; pH 7.2
RUO

For Research Use Only.

Provide Content Correction

The Fisher Scientific Encompass Program offers items which are not part of our distribution portfolio. These products typically do not have pictures or detailed descriptions. However, we are committed to improving your shopping experience. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit