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  6. CD146/MCAM Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech 

CD146/MCAM Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
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Catalog No. 501731648 Shop All Proteintech Group Inc Products
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50-173-1648 150 μL
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Catalog No. 50-173-1648 Supplier Proteintech Group Inc Supplier No. 175641AP150UL
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Description

Rabbit Polyclonal Antibody

CD146 (MCAM) is an integral membrane glycoprotein belonging to the immunoglobulin superfamily. CD146 is expressed at cell-cell junctions in all endothelial cells, and has also been observed in other normal and maligt cell types. In addition to its recognized role as a calcium-independent cell adhesion molecule, CD146 may also act as a signal transduction molecule in the recruitment of Fyn kinase, and in the subsequent tyrosine-phosphorylation of intracellular proteins involved in actin cytoskeleton assembly. CD146 plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. CD146 expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Further, CD146 could be an adhesion molecule active in neural crest cells during embryonic development. CD146 acts also as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2, and a transient increase in the intracellular calcium concentration.

Specifications

Antigen CD146/MCAM
Applications Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation
Classification Polyclonal
Concentration 0.4 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene MCAM
Gene Accession No. P43121, Q8R2Y2, Q9EPF2
Gene Alias CD146, MCAM, MUC18
Gene Symbols MCAM
Host Species Rabbit
Immunogen CD146/MCAM Fusion Protein Ag11762
Purification Method Antigen Affinity Chromatography
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4162, 78967, 84004
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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