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Invitrogen™ CD177 Monoclonal Antibody (MEM-166)
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Catalog No. 01676014
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100 μg
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Catalog No. Quantity
01-676-014 100 μg
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Catalog No. 01-676-014 Supplier Invitrogen™ Supplier No. MA119250
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Description

Mouse Monoclonal Antibody

This antibody reacts with CD177 (Neutrophil specific antigen 1), a 60 kDa GPI-linked cell surface glycoprotein of uPAR family, expressed on granulocytes and in bone marrow early erythroblasts, megakaryocytes, promyelocytes and myelocytes. Western blot should be performed under non-reducing conditions.

CD177 (NB1/HNA-2a and PRV-1 form) is a GPI-anchored glycoprotein present mainly on neutrophils. Its plasma membrane expression is increased during pregnancy and and inflammation or after G-CSF application. Ligand of CD177 has been identified as CD31 (PECAM-1). CD177 participates in neutrophil transmigration and seems to be also a pro-proliferative molecule. The antibodies against CD177 can be involved in neonatal alloimmune neutropenia (NAN).
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Specifications

Antigen CD177
Applications Flow Cytometry, Immunoprecipitation, Western Blot
Classification Monoclonal
Clone MEM-166
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 15mM sodium azide; pH 7.4
Gene CD177
Gene Accession No. Q8N6Q3
Gene Alias 1190003K14Rik; CD177; CD177 antigen; CD177 molecule; cell surface receptor; HNA2A; HNA-2a; Human neutrophil alloantigen 2a; NB1; NB1 glycoprotein; NB1 GP; Pdp3; Polycythemia rubra vera protein 1; PRV1; PRV-1; RGD1562941; UNQ595/PRO1181
Gene Symbols CD177
Host Species Mouse
Immunogen Human granulocytes.
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 57126
Target Species Human, Monkey
Content And Storage 4°C, do not freeze
Product Type Antibody
Form Liquid
Isotype IgG1
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