Invitrogen™ CD179b Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA575839

Catalog No. PIPA575839

Description

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

The preB cell receptor, CD179b, is found on the surface of proB and preB cells, where it is involved in transduction of signals for cellular proliferation and differentiation from the proB cell to the preB cell stage, allelic exclusion at the Ig heavy chain gene locus, and promotion of Ig light chain gene rearrangements. The preB cell receptor is composed of a membrane-bound Ig mu heavy chain in association with a heterodimeric surrogate light chain. This gene encodes one of the surrogate light chain subunits and is a member of the immunoglobulin gene superfamily. Mutations in this gene can result in B cell deficiency and agammaglobulinemia, an autosomal recessive disease in which few or no gamma globulins or antibodies are made. Two transcript variants encoding different isoforms have been found for this gene.

Specifications

• Antigen: CD179b
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: IGLL1
• Gene Alias: 14.1; AGM2; BB139905; CD179 antigen-like family member B; CD179b; CD179b antigen; ig lambda-5; IGL1; IGL5; Igl-5; IGLJ IGLL; IGLJ14.1; Igll; Igll1; IGO; IGVPB; immunoglobulin lambda chain 5; immunoglobulin lambda like polypeptide 1; immunoglobulin lambda-like polypeptide 1; immunoglobulin lambda-like polypeptide 5; Immunoglobulin omega polypeptide; immunoglobulin omega polypeptide chain; immunoglobulin-related 14.1 protein; immunoglobulin-related protein 14.1; lambda 5; lambda5; Pre-B lymphocyte-specific protein-2; VPREB2
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 3543
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P15814
• Gene Symbols: IGLL1
• Immunogen: Synthetic peptide corresponding to residues in Human CD179b.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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