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CD181 (CXCR1) Rat anti-Mouse, PE, Clone: U45-632, BD

Rat Monoclonal Antibody

Manufacturer:  BD Biosciences 566383

Catalog No. BDB566383

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The U45-632 monoclonal antibody specifically binds to mouse CD181, also known as C-X-C chemokine receptor type 1 (CXCR1) or IL-8 receptor . CD181 is a chemokine receptor of the G-protein coupled receptor 1 family, also known as seven-transmembrane domain receptors. In the mouse, which is not known to express IL-8 (CXCL8), CD181 binds to mouse GCP-2 (CXCL6). Mouse CD181 can also bind to human IL-8. CD181 is expressed by neutrophils, which are activated upon ligand binding. The chemokine receptors CXCR1 and CXCR2 play an important role in mediating neutrophil recruitment and neutrophil-dependent injury in several models of inflammation.

R-phycoerythrin (PE) is an accessory photosynthetic pigment found in red algae. It exists in vitro as a 240-kDa protein with 23 phycoerythrobilin chromophores per molecule. This makes PE one of the brightest fluorochromes for flow cytometry applications, but its photobleaching properties make it unsuitable for fluorescence microscopy.


CD181 (CXCR1)
Aqueous buffered solution containing ≤0.09% sodium azide.
Il8ra,Cxcr1,C-X-C chemokine receptor type 1, CXC-R1, CXCR-1, IL-8R A
Mouse CD181 Recombinant Protein
The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography. The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed.
Affinity Purified
Rat LEW, also known as Lewis IgG2b, κ
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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