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  6. MilliporeSigma™ CD19, Mouse, APC, Clone: SJ25C1,

MilliporeSigma™ CD19, Mouse, APC, Clone: SJ25C1,

Catalog No. p-7083542 Shop All MilliporeSigma Products
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MABF1644 25 Tests
MABF1646 500 Tests
MABF1645 100 Tests
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Description

Mouse Monoclonal Antibody

The SJ25C1 antibody reacts with human CD19, a 95kDa glycoprotein which acts as a co-receptor, along with CD21 (CR2), CD81 (TAPA-1) and CD225 (Leu13), in support of the functional B cell receptor (BCR). This complex provides antigen-specific recognition and subsequent activation of B cells to proliferate and differentiate into antibody-secreting cells (plasma cells) or memory B cells, which are crucial for secondary antigen encounter. Upon activation and tyrosine phosphorylation, the CD19 molecule can provide an anchor for cytoplasmic signaling proteins such as GRB2, SOS or PLCG2. CD19 is a lineage-differentiation marker, as its expression is detectable at the earliest B cell stages, through development, and is finally lost upon transition to mature plasma cells.

The SJ25C1 antibody is widely used as a phenotypic marker for CD19 expression on B cells, as well as on dendritic cell subsets.

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD19
Applications Flow Cytometry
Classification Monoclonal
Clone SJ25C1
Concentration Please refer to lot specific datasheet.
Conjugate APC
Formulation Purified mouse monoclonal in buffer containing 10mM NaH2PO4, 150mM NaCl, 0.09% NaN3, 0.1% gelatin, pH7.2.
Gene CD19
Gene Accession No. P15391
Host Species Mouse
Immunogen Immunogen information for this antibody is proprietary information.
Purification Method Purified by size-exclusion chromatography
Quantity 25 Tests
Regulatory Status RUO
Research Discipline Inflammation & Immunology
Primary or Secondary Primary
Target Species Human
Content And Storage Stable for 1 year at 2°-8°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
Form Purified
Isotype IgG1 κ
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For Research Use Only. Not for use in diagnostic procedures.

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