CD192 (CCR2) Mouse anti-Human, Brilliant Violet 421, Clone: 48607, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 564067

Catalog No. BDB564067

Description

The 48607 monoclonal antibody specifically binds to CD192 which is also known as, Chemokine C-C motif receptor 2 (CCR2), Monocyte chemoattractant protein 1 receptor (MCP-1 receptor/MCP-1-R), or CKR2. CD192 is a seven-transmembrane, G-protein-coupled receptor that is the specific receptor for Monocyte chemoattractant protein 1 (MCP-1/CCL2), MCP-2/CCL8, MCP-3/CCL7, and MCP-4/CCL13. CD192 is expressed on monocytes, dendritic cells, NK cells, basophils, and activated T cells and B cells. CD192 exists in two forms, CD192A and CD192B. The two forms are derived from alternatively spliced variants of a single gene and differ at the C-terminal end. CD192 plays an important role in inflammatory responses.

The antibody was conjugated to BD Horizon BV421 which is part of the BD Horizon Brilliant™ Violet family of dyes. With an Ex Max of 407nm and Em Max at 421nm, BD Horizon BV421 can be excited by the violet laser and detected in the standard Pacific Blue™ filter set (eg, 450/50nm filter). BD Horizon BV421 conjugates are very bright, often exhibiting a 10 fold improvement in brightness compared to Pacific Blue conjugates. BV421 is a polymer-based dye excited by the violet laser and is one of the brightest fluorochromes offered by BD Biosciences. Conjugates are typically 10 times brighter than Pacific Blue™ conjugates and are often as bright as or brighter than PE conjugates. Due to nearly identical excitation and emission properties but different spillover characteristics, BD Horizon BV421, Pacific Blue™, and BD Horizon™ V450 cannot be used simultaneously.

Specifications

• Antigen: CD192
• Clone: 48607
• Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
• Host Species: Mouse
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Target Species: Human
• Isotype: IgG2b

• Classification: Monoclonal
• Conjugate: Brilliant Violet 421
• Gene Alias: CCR2, MCP-1-R, CC-CKR-2, CMKBR2, CKR2, CCR2A, CCR2B, CKR2A, CKR2B
• Immunogen: Human hCCR2-transfected NS0 Cells
• Quantity: 50 Tests
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.