Invitrogen™ CD205 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA587607

Catalog No. PIPA587607

Description

Positive Samples: Mouse lung; Cellular Location: Membrane, Single-pass type I membrane protein Immunogen sequence: CEDNWEKNEQ FGSCYQFNTQ TALSWKEAYV SCQNQGADLL SINSAAELTY LKEKEGIAKI FWIGLNQLYS ARGWEWSDHK PLNFLNWDPD RPSAPTIGGS SCARMDAESG LWQSFSCEAQ LPYVCRKPLN NTVELTDVWT YSDTRCDAGW LPNNGFCYLL VNESNSWDKA HAKCKAFSSD LISIHSLADV EVVVTKLHNE DIKEEVWIGL KNINIPTLFQ WSDGTEVTLT YWDENEPNVP YNKTPNCVSY LGELGQWKVQ SCEEKLKYVC KRKGEKLNDA SSDKMC.

CD205 (LY25, Lymphocyte Antigen 75) is an integral membrane glycoprotein involved in antigen uptake, trafficking and presentation that improves the induction of antigen-specific T cell immunity. CD205 is highly expressed by CD8+ dendritic cells (DCs) and also expressed at different levels by bone marrow Gr1+ cells, Langerhans cells, (BMDC) bone marrow derived DCs and thymic epithelial cells. CD205 acts as an endocytic receptor that directs captured antigens to the extracellular space towards a specialized antigen processing region. Further, CD205 also prompts the reduced proliferation of B lymphocytes. Diseases associated with CD205 dysfunction include pneumonic plague and lipid pneumonia.

Specifications

• Antigen: CD205
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: LY75
• Gene Alias: CA-IX; CD205; CLEC13B; C-type lectin domain family 13 member B; DCL-1 fusion; DEC205; DEC-205; DEC-205/CD205 protein; gp200; gp200-MR6; group VI C-type animal lectin; LY75; ly-75; Lymphocyte antigen 75; membrane antigen MN; P54/58N; pMW1; RGD1565962; RP23-10L17.4
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 17076, 4065
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 1.15 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: O60449, Q60767
• Gene Symbols: LY75
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 216-501 of human LY75 (NP_0023402).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG