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  6. Invitrogen™ CD226 (DNAM-1) Monoclonal Antibody (11A8.7.4), APC, eBioscience™ 

Invitrogen™ CD226 (DNAM-1) Monoclonal Antibody (11A8.7.4), APC, eBioscience™
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Catalog No. p-7169316
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100 Tests
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Catalog No. Quantity
17-226-942 100 Tests
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Catalog No. 17-226-942 Supplier Invitrogen™ Supplier No. 17226942
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Description

Mouse Monoclonal Antibody

The monoclonal antibody 11A8.7.4 reacts to DNAM-1 also known as CD226. DNAM 1 is a 65 kD receptor expressed by peripheral blood T lymphocytes that is involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T lymphocytes. DNAM 1 is broadly expressed on T cells, NK cells, platelets, monocytes and a subset of B cells. DNAM-1 is also expressed by a subset of CD3 positive thymocytes. The ligands for CD226 are the poliovirus receptor (PVR, CD155) and Poliovirus Related Receptor (PPR2, Nectin-2, CD112). CD226 is involved in cytolytic activity by interacting with integrins and activating protein tyrosine kinase Fyn. The 11A8.7.4 antibody has been shown to increase T and NK cell-mediated cytotoxicity. Applications Reported: This 11A8.7.4 antibody has been reported for use in flow cytometric analysis. Applications Tested: This 11A8.7.4 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at 5 μL (0.25 μg) per test. A test is defined as the amount ( μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser.

DNAM 1 is a receptor expressed by peripheral blood T lymphocytes that is involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T lymphocytes. DNAM 1 is broadly expressed on T cells, NK cells, platelets, monocytes and a subset of B cells. DNAM-1 is also expressed by a subset of CD3 positive thymocytes.
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Specifications

Antigen CD226 (DNAM-1)
Applications Flow Cytometry
Classification Monoclonal
Clone 11A8.7.4
Concentration 5 μL/Test
Conjugate APC
Formulation PBS with BSA and 0.09% sodium azide; pH 7.2
Gene Cd226
Gene Accession No. Q15762
Gene Alias adhesion glycoprotein; BC051526; Cd226; CD226 antigen; CD226 molecule; DNAM 1; DNAM1; DNAM-1; DNAX accessory molecule 1; DNAX accessory molecule-1; platelet and T cell activation antigen 1; platelet and T-cell activation antigen 1; Pta1; T lineage-specific activation antigen 1 antigen; TLiSA1
Gene Symbols Cd226
Host Species Mouse
Purification Method Affinity chromatography
Quantity 100 Tests
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10666
Target Species Human
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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