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  6. Invitrogen™ CD235a Monoclonal Antibody (CLB-ery-1 (AME-1)), FITC 

Invitrogen™ CD235a Monoclonal Antibody (CLB-ery-1 (AME-1)), FITC
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Catalog No. MHGLA01
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500 μL
2 mL
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MHGLA01 500 μL
MHGLA014 2 mL
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Catalog No. MHGLA01 Supplier Invitrogen™ Supplier No. MHGLA01
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Description

Mouse Monoclonal Antibody

Commonly used, FITC conjugates provide relatively high absorptivity, excellent fluorescence quantum yield, and good water solubility. This antibody recognizes a papain-sensitive epitope in the extracellular domain of the sialoglycoprotein known as glycophorin A (CD235a).

Glycophorin A, also known as CD235a, is a 151 amino acid sialoglycoprotein expressed on the membrane of mature erythrocytes and erythroid progenitor cells, with approximately 500,000 copies per cell. The gene for glycophorin A is located on chromosome 4 and exists in two allelic forms, M and N, which differ by two amino acids: the M group has Ser1 and Gly5, while the N group has Leu1 and Glu5. These allelic variations define the blood group M and N specificities. Glycophorin A serves multiple functions, including providing a mucin-like barrier that minimizes aggregation between red blood cells in circulation, potentially preventing cell fusion. It also acts as a receptor for certain pathogens, including Sandei virus, parvovirus, and Hsa, a Streptococcus adhesin. Recent studies suggest that exposure to toxins can lead to mutations or loss of alleles, resulting in phenotypic changes. There is ongoing research correlating genotype and phenotype with predisposition to diseases such as cancer and heart disease, highlighting the importance of glycophorin A in both health and disease. Glycophorin A is a significant marker for studying erythrocyte-related functions and pathologies, as well as its role in pathogen interactions and disease predisposition.
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Specifications

Antigen CD235a
Applications Flow Cytometry
Classification Monoclonal
Clone CLB-ery-1 (AME-1)
Conjugate FITC
Formulation PBS with BSA and 0.1% sodium azide
Gene GYPA
Gene Accession No. P02724
Gene Alias AI853584; CD235; CD235a; erythroid-lineage-specific membrane sialoglycoprotein; glycophorin A; glycophorin A (MN blood group); glycophorin A (MNS blood group); glycophorin A, GPA; glycophorin Erik; glycophorin MiI; glycophorin MiV; glycophorin SAT; glycophorin Sta type C; glycophorin-A; GPA; GPErik; GPSAT; Gypa; HGNC:4702; HGpMiV; HGpMiX; HGpMiXI; HGpSta(C); HGpStaC; Mi.V glycoprotein; Mi.V glycoprotein (24 AA); MN; MN sialoglycoprotein; MNS; PAS-2; recombinant glycophorin A-B Miltenberger-DR; sialoglycoprotein alpha
Gene Symbols GYPA
Host Species Mouse
Immunogen Human Glycophorin A (CD235a).
Purification Method Purified
Quantity 500 μL
Regulatory Status ASR
Primary or Secondary Primary
Gene ID (Entrez) 2993
Target Species Human
Content And Storage 4°C, store in dark
Product Type Antibody
Form Liquid
Isotype IgG1
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