Invitrogen™ CD235a Monoclonal Antibody (CLB-ery-1 (AME-1)), PE

Catalog No.	Quantity
MHGLA044	2 mL
MHGLA04	500 μL

Catalog No. MHGLA044 Supplier Invitrogen™ Supplier No. MHGLA044

Description

Mouse Monoclonal Antibody

R-phycoerythrin (PE) is a stable and highly soluble phycobiliprotein which provides maximal absorbance and fluorescence without susceptibility to internal or external fluorescence quenching, thus providing an exceptional quantum yields and molar extinction coefficients. This antibody recognizes a papain-sensitive epitope in the extracellular domain of the sialoglycoprotein known as glycophorin A (CD235a).

Glycophorin A, also known as CD235a, is a 151 amino acid sialoglycoprotein expressed on the membrane of mature erythrocytes and erythroid progenitor cells, with approximately 500,000 copies per cell. The gene for glycophorin A is located on chromosome 4 and exists in two allelic forms, M and N, which differ by two amino acids: the M group has Ser1 and Gly5, while the N group has Leu1 and Glu5. These allelic variations define the blood group M and N specificities. Glycophorin A serves multiple functions, including providing a mucin-like barrier that minimizes aggregation between red blood cells in circulation, potentially preventing cell fusion. It also acts as a receptor for certain pathogens, including Sandei virus, parvovirus, and Hsa, a Streptococcus adhesin. Recent studies suggest that exposure to toxins can lead to mutations or loss of alleles, resulting in phenotypic changes. There is ongoing research correlating genotype and phenotype with predisposition to diseases such as cancer and heart disease, highlighting the importance of glycophorin A in both health and disease. Glycophorin A is a significant marker for studying erythrocyte-related functions and pathologies, as well as its role in pathogen interactions and disease predisposition.

Specifications

• Antigen: CD235a
• Applications: Flow Cytometry
• Classification: Monoclonal
• Clone: CLB-ery-1 (AME-1)
• Conjugate: PE
• Formulation: PBS with 4mg/mL BSA, sucrose and 0.1% sodium azide
• Gene: GYPA
• Gene Accession No.: P02724
• Gene Alias: AI853584; CD235; CD235a; erythroid-lineage-specific membrane sialoglycoprotein; glycophorin A; glycophorin A (MN blood group); glycophorin A (MNS blood group); glycophorin A, GPA; glycophorin Erik; glycophorin MiI; glycophorin MiV; glycophorin SAT; glycophorin Sta type C; glycophorin-A; GPA; GPErik; GPSAT; Gypa; HGNC:4702; HGpMiV; HGpMiX; HGpMiXI; HGpSta(C); HGpStaC; Mi.V glycoprotein; Mi.V glycoprotein (24 AA); MN; MN sialoglycoprotein; MNS; PAS-2; recombinant glycophorin A-B Miltenberger-DR; sialoglycoprotein alpha
• Gene Symbols: GYPA
• Host Species: Mouse
• Immunogen: Human Glycophorin A (CD235a).
• Purification Method: Purified
• Quantity: 2 mL
• Regulatory Status: ASR
• Primary or Secondary: Primary
• Gene ID (Entrez): 2993
• Target Species: Human
• Content And Storage: 4°C, store in dark
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1