CD244 Monoclonal Antibody (OTI1C11), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA812271

Catalog No. 50-168-4493

Description

CD244 (2B4, SLAMF4) is a cell surface receptor expressed on natural killer (NK) cells (and some T cells) that mediate non-major histocompatibility complex (MHC) restricted killing. The interaction between NK-cell and target cells via CD244 is thought to modulate NK-cell cytolytic activity. CD244 interacts with SLAMF2, causing the activation of both SLAMF4- and SLAMF2-expressing cells. Patients with systemic lupus erythmatosus have lower than normal levels of SLAMF4 expressed on their NK cells and monocytes, suggesting that SLAMF4 may play a role in the pathology of this autoimmune disease. Diseases associated with CD244 dysfunction include rheumatoid arthritis and lymphoproliferative syndrome. Alternatively spliced transcript variants encoding different isoforms of CD244 have been found for this gene.

Specifications

• Antigen: CD244
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: Q9BZW8
• Gene Symbols: CD244
• Immunogen: Full length human recombit protein of human CD244 produced in HEK293T cell.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Western Blot
• Clone: OTI1C11
• Conjugate: Unconjugated
• Gene: CD244
• Gene Alias: 2B4, NAIL, NKR2B4, Nmrk, SLAMF4
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 51744
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid